› 6zu8

X-ray diffraction
1.95Å resolution

Crystal structure of human Brachyury G177D variant in complex with Afatinib

Released:
DOI: 10.2210/pdb6zu8/pdb
PDB entry 6zu8 coloured by chain, front view.
PDB entry 6zu8 coloured by chain, side view.
PDB entry 6zu8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Shrestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-224; Coverage: 42%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand 0WN 1 x 0WN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 43.107Å b: 49.269Å c: 83.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.26
Expression system: Escherichia coli

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