› 6zxr

X-ray diffraction
2.31Å resolution

Crystal structure of the KDEL receptor bound to RDEL peptide at pH 6.0

Released:
DOI: 10.2210/pdb6zxr/pdb
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PDB entry 6zxr coloured by chain, front view.
PDB entry 6zxr coloured by chain, side view.
PDB entry 6zxr coloured by chain, top view.
Source organisms:
Primary publication:
A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval.
Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin PC, Barr FA, Newstead S
OpenAccess logo Elife 10 (2021)
PMID: 34137369

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178555 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ER lumen protein-retaining receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 25.33 KDa
Source organism: Gallus gallus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q5ZKX9 (Residues: 1-212; Coverage: 100%)
Gene names: KDELR2, RCJMB04_8l23
Sequence domains: ER lumen protein retaining receptor
ALA-GLU-ARG-ASP-GLU-LEU Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 733 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P21
Unit cell:
a: 47.52Å b: 37.45Å c: 62.65Å
α: 90° β: 95.11° γ: 90°
R-values:
R R work R free
0.203 0.2 0.257
Expression systems:
  • Saccharomyces cerevisiae
  • Not provided

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Citations

2 review citations

KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities.
Cela et al. (2022)
1 more

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