7abe

X-ray diffraction
1.83Å resolution

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-769

Released:
Source organism: Homo sapiens
Entry authors: Singh AK, Blaazer AR, Zara L, de Esch IJP, Leurs R, Brown DG

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-170654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3',5'-cyclic-AMP phosphodiesterase 4D Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 364 amino acids
Theoretical weight: 41.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08499 (Residues: 381-740; Coverage: 45%)
Gene names: DPDE3, PDE4D
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 98.701Å b: 111.245Å c: 160.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.208
Expression system: Escherichia coli BL21(DE3)