› 7c73

X-ray diffraction
2.7Å resolution

Crystal structure of yak lactoperoxidase using data obtained from crystals soaked in MgCl2 at 2.70 A resolution

Released:
DOI: 10.2210/pdb7c73/pdb
PDB entry 7c73 coloured by chain, front view.
PDB entry 7c73 coloured by chain, side view.
PDB entry 7c73 coloured by chain, top view.
Source organism: Bos mutus
Primary publication:
Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution.
Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S, Singh TP
J Biol Inorg Chem 26 149-159 (2021)
PMID: 33427997

Function and Biology Details

Reaction catalysed: 
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125871 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoperoxidase Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.85 KDa
Source organism: Bos mutus
UniProt:
  • Canonical: L8ICE9 (Residues: 118-712; Coverage: 86%)
Gene name: M91_18575
Sequence domains: Animal haem peroxidase

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
2 bound ligands:
Ligand CA 2 x CA
Ligand NAG 3 x NAG
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: P21
Unit cell:
a: 53.88Å b: 79.93Å c: 75.05Å
α: 90° β: 101.35° γ: 90°
R-values:
R R work R free
0.222 0.218 0.306

Quick links

Citations

1 citations in other articles

Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase.
Singh et al. (2022)