› 7d0z

Solution NMR

NMR solution structures of the DNA minidumbbell formed by two CCTG repeats at pH 5

Released:
DOI: 10.2210/pdb7d0z/pdb
PDB entry 7d0z coloured by chain, ensemble of 20 models, front view.
PDB entry 7d0z coloured by chain, ensemble of 20 models, side view.
PDB entry 7d0z coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
5-Methylcytosine Substantially Enhances the Thermal Stability of DNA Minidumbbells.
Wan L, Yi J, Lam SL, Lee HK, Guo P
Chemistry 27 6740-6747 (2021)
PMID: 33501691

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-121186 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*(DCZ)P*CP*TP*GP*CP*CP*TP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.3 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NA 5 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

2 mentions without citation

Structures and conformational dynamics of DNA minidumbbells in pyrimidine-rich repeats associated with neurodegenerative diseases.
Liu et al. (2023)
1 more