› 7diz

X-ray diffraction
1.8Å resolution

Structure of PfGrx1 in the reduced state using DTT

Released:
DOI: 10.2210/pdb7diz/pdb
PDB entry 7diz coloured by chain, front view.
PDB entry 7diz coloured by chain, side view.
PDB entry 7diz coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Manickam Y, Sharma A

Function and Biology Details

Reaction catalysed: 
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-1 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.44 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli M15
UniProt:
  • Canonical: Q9NLB2 (Residues: 1-111; Coverage: 100%)
Gene name: PF3D7_0306300
Sequence domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand MPO 1 x MPO
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3221
Unit cell:
a: 48.357Å b: 48.357Å c: 82.383Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 0.156 0.177
Expression system: Escherichia coli M15

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