› 7f0j

Electron Microscopy
2.9Å resolution

CryoEM structure of human Kv4.2

Released:
DOI: 10.2210/pdb7f0j/pdb
PDB entry 7f0j coloured by chain, front view.
PDB entry 7f0j coloured by chain, side view.
PDB entry 7f0j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O
OpenAccess logo Nature 599 158-164 (2021)
PMID: 34552243
Related structures: EMD-31399

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A-type voltage-gated potassium channel KCND2 Chains: B, C, F, H
Molecule details ›
Chains: B, C, F, H
Length: 630 amino acids
Theoretical weight: 70.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZV8 (Residues: 1-630; Coverage: 100%)
Gene names: KCND2, KIAA1044
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.9Å
Relevant EMDB volumes: EMD-31399
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Sensing sound: Cellular specializations and molecular force sensors.
Qiu et al. (2022)
6 more

1 mention without citation

Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats.
Liu et al. (2022)