› 7jvd

X-ray diffraction
2.3Å resolution

Fab of 5.6 monoclonal mouse IgG1 co-crystallized with the trisaccharide form of serotype 3 pneumococcal capsular polysaccharide

Released:
DOI: 10.2210/pdb7jvd/pdb
PDB entry 7jvd coloured by chain, front view.
PDB entry 7jvd coloured by chain, side view.
PDB entry 7jvd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies.
Ozdilek A, Huang J, Babb R, Paschall AV, Middleton DR, Duke JA, Pirofski LA, Mousa JJ, Avci FY
OpenAccess logo mBio 12 e0080021 (2021)
PMID: 34061603

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214343 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
5.6 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Mus musculus
5.6 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, BDP
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 49.516Å b: 134.302Å c: 133.119Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.183 0.221
Expression system: Mus musculus

Quick links

Citations

3 review citations

Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets.
Aceil et al. (2022)
2 more

1 mention without citation

A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies.
Ozdilek et al. (2021)