› 7nry

X-ray diffraction
3.8Å resolution

Re-refinement of MAPKAP kinase-2/inhibitor complex 3fyj

Released:
DOI: 10.2210/pdb7nry/pdb
PDB entry 7nry coloured by chain, front view.
PDB entry 7nry coloured by chain, side view.
PDB entry 7nry coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adaptive Cartesian and torsional restraints for interactive model rebuilding.
Croll TI, Read RJ
OpenAccess logo Acta Crystallogr D Struct Biol 77 438-446 (2021)
PMID: 33825704

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-activated protein kinase 2 Chain: X
Molecule details ›
Chain: X
Length: 327 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49137 (Residues: 45-371; Coverage: 82%)
Gene name: MAPKAPK2
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand B97 1 x B97
Ligand CL 1 x CL
Ligand MLA 1 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: F4132
Unit cell:
a: 255.551Å b: 255.551Å c: 255.551Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Structural basis of human telomerase recruitment by TPP1-POT1.
Sekne et al. (2022)
5 more