› 7ojo

X-ray diffraction
2.3Å resolution

Tankyrase 2 in complex with two small molecule fragments

Released:
DOI: 10.2210/pdb7ojo/pdb
PDB entry 7ojo coloured by chain, front view.
PDB entry 7ojo coloured by chain, side view.
PDB entry 7ojo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sowa ST, Lehtio L

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190550 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-2 Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 171 amino acids
Theoretical weight: 19.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2K2 (Residues: 946-1114; Coverage: 15%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Poly [ADP-ribose] polymerase tankyrase-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 48 amino acids
Theoretical weight: 5.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2K2 (Residues: 1115-1162; Coverage: 4%)
Gene names: PARP5B, TANK2, TNKL, TNKS2

Ligands and Environments

4 bound ligands:
Ligand WQG 2 x WQG
Ligand VGZ 2 x VGZ
Ligand ZN 2 x ZN
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P212121
Unit cell:
a: 41.645Å b: 76.386Å c: 148.875Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.277
Expression system: Escherichia coli

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