› 7qfe

X-ray diffraction
2.2Å resolution

Crystal structure of Human Serum albumin in complex with Gemfibrozil

Released:
DOI: 10.2210/pdb7qfe/pdb
PDB entry 7qfe coloured by chain, front view.
PDB entry 7qfe coloured by chain, side view.
PDB entry 7qfe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Analysis of Human Serum Albumin in Complex with the Fibrate Drug Gemfibrozil.
Liberi S, Linciano S, Moro G, De Toni L, Cendron L, Angelini A
OpenAccess logo Int J Mol Sci 23 (2022)
PMID: 35163693

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family

Ligands and Environments

6 bound ligands:
Ligand MYR 2 x MYR
Ligand 4TX 2 x 4TX
Ligand PGE 1 x PGE
Ligand PG4 1 x PG4
Ligand MPD 6 x MPD
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 184.897Å b: 38.642Å c: 96.213Å
α: 90° β: 104.58° γ: 90°
R-values:
R R work R free
0.223 0.219 0.255
Expression system: Komagataella pastoris

Quick links

Citations

4 citation in other articles

Investigation of the Interaction between Human Serum Albumin and Branched Short-Chain Perfluoroalkyl Compounds.
Moro et al. (2022)
3 more

2 mentions without citation

Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease.
Sánchez-Ospina et al. (2024)
1 more