› 7sit

X-ray diffraction
3.32Å resolution

Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m

Released:
DOI: 10.2210/pdb7sit/pdb
Model geometry
Fit model/data
PDB entry 7sit coloured by chain, front view.
PDB entry 7sit coloured by chain, side view.
PDB entry 7sit coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel.
Reddi R, Matulef K, Riederer EA, Whorton MR, Valiyaveetil FI
OpenAccess logo Sci Adv 8 eabm8804 (2022)
PMID: 35452285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158618 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Voltage-gated potassium channel subunit beta-2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 333 amino acids
Theoretical weight: 37.35 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P62483 (Residues: 35-367; Coverage: 91%)
Gene names: Ckbeta2, Kcnab2, Kcnb3
Sequence domains: Aldo/keto reductase family
Potassium voltage-gated channel subfamily A member 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 514 amino acids
Theoretical weight: 58.82 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P63142 (Residues: 1-499; Coverage: 99%)
Gene name: Kcna2
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAP 2 x NAP
Ligand K 4 x K
Ligand O 1 x O
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P4212
Unit cell:
a: 129.587Å b: 129.587Å c: 278.482Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.251 0.289
Expression system: Komagataella pastoris

Quick links

Citations

11 citation in other articles

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Selvakumar et al. (2022)
10 more

2 mentions without citation

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.
Chandy et al. (2023)
1 more

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO