› 7u6d

Electron Microscopy
5.03Å resolution

Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459

Released:
DOI: 10.2210/pdb7u6d/pdb
PDB entry 7u6d coloured by chain, front view.
PDB entry 7u6d coloured by chain, side view.
PDB entry 7u6d coloured by chain, top view.
Source organisms:
Primary publication:
Activation of the human insulin receptor by non-insulin-related peptides.
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martínez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC
OpenAccess logo Nat Commun 13 5695 (2022)
PMID: 36171189
Related structures: EMD-26363

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138944 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IM459 Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 4 KDa
Source organism: synthetic construct
Expression system: Not provided
Insulin receptor subunit alpha Chains: B, C
Molecule details ›
Chains: B, C
Length: 916 amino acids
Theoretical weight: 104.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06213 (Residues: 28-955; Coverage: 68%)
  • Best match: P06213-2 (Residues: 28-943)
Gene name: INSR
Sequence domains:

Ligands and Environments

No bound ligands
2 modified residues:
Ligand AIB 1 x AIB
Ligand 0A1 1 x 0A1

Experiments and Validation Details

Entry percentile scores
Resolution: 5.03Å
Relevant EMDB volumes: EMD-26363
Expression systems:
  • Not provided
  • Cricetulus griseus

Quick links

Citations

1 review citation

A stepwise activation model for the insulin receptor.
Yunn et al. (2023)
2 other articles