› 7vue

X-ray diffraction
2.6Å resolution

Structural insight of the molecular mechanism of cilofexor bound to FXR

Released:
DOI: 10.2210/pdb7vue/pdb
PDB entry 7vue coloured by chain, front view.
PDB entry 7vue coloured by chain, side view.
PDB entry 7vue coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.
Jiang L, Liu X, Wei H, Dai S, Qu L, Chen X, Guo M, Chen Y
Biochem Biophys Res Commun 595 1-6 (2022)
PMID: 35091108

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 26.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RI1 (Residues: 259-484; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.71 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-753; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 811 1 x 811
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: F23
Unit cell:
a: 156.756Å b: 156.756Å c: 156.756Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.212 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Gene Therapy for Acquired and Genetic Cholestasis.
Martínez-García et al. (2022)