› 7vwg

X-ray diffraction
2.2Å resolution

Human peroxisome proliferator-activated receptor (PPAR) delta ligand binding domain in complex with a synthetic alpha/delta dual agonist JKPL38

Released:
DOI: 10.2210/pdb7vwg/pdb
PDB entry 7vwg coloured by chain, front view.
PDB entry 7vwg coloured by chain, side view.
PDB entry 7vwg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor delta in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative.
Oyama T, Takiguchi K, Miyachi H
Acta Crystallogr F Struct Biol Commun 78 81-87 (2022)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169864 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand B7G 2 x B7G
Ligand 820 2 x 820
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P21
Unit cell:
a: 39.5Å b: 94.314Å c: 96.247Å
α: 90° β: 97.372° γ: 90°
R-values:
R R work R free
0.202 0.2 0.232
Expression system: Escherichia coli

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