PDB 7yq5 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Biochemical function:

hormone activity

Biological process:

not assigned

Cellular component:

extracellular region

Sequence domains:

4 more domains

Structure analysis Details

Assembly composition:

hetero pentamer (preferred)

Assembly name:

Insulin complex and DNA (preferred)

PDBe Complex ID:

PDB-CPX-220401 (preferred)

Entry contents:

3 distinct polypeptide molecules
1 distinct DNA molecule

Macromolecules (4 distinct):

Insulin A chain Chain: A

Molecule details ›

Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P01308 (Residues: 90-110; Coverage: 24%)

Gene name: INS

Insulin, isoform 2 Chain: B

Molecule details ›

Chain: B
Length: 25 amino acids
Theoretical weight: 2.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: F8WCM5 (Residues: 27-51; Coverage: 13%)

Gene name: INS-IGF2

Insulin receptor subunit alpha Chains: E, F

Molecule details ›

Chains: E, F
Length: 907 amino acids
Theoretical weight: 103.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P06213 (Residues: 28-946; Coverage: 67%)
Best match: P06213-2 (Residues: 28-934)

Gene name: INSR
Sequence domains: