7yq6

Electron Microscopy
4.18Å resolution

human insulin receptor bound with A62 DNA aptamer

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-122345 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Insulin receptor subunit alpha Chains: E, F
Molecule details ›
Chains: E, F
Length: 907 amino acids
Theoretical weight: 103.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06213 (Residues: 28-946; Coverage: 67%)
  • Best match: P06213-2 (Residues: 28-934)
Gene name: INSR
Sequence domains:
IR-A62 aptamer Chains: G, H
Molecule details ›
Chains: G, H
Length: 24 nucleotides
Theoretical weight: 8.53 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
Resolution: 4.18Å
Relevant EMDB volumes: EMD-34021
Expression systems:
  • Homo sapiens
  • Not provided