› 7ys9

X-ray diffraction
1.65Å resolution

Crystal Structure of UDP-glucose 4-epimerase (Rv3634c) in complex with both UDP-Glucose and UDP-Galactose in chainA from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb7ys9/pdb
PDB entry 7ys9 coloured by chain, front view.
PDB entry 7ys9 coloured by chain, side view.
PDB entry 7ys9 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Yadav S, Bhatia I, Biswal BK

Function and Biology Details

Reaction catalysed: 
UDP-alpha-D-glucose = UDP-alpha-D-galactose
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 4-epimerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 320 amino acids
Theoretical weight: 34.45 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WN67 (Residues: 1-314; Coverage: 100%)
Gene names: Rv3634c, galE1
Sequence domains: NAD dependent epimerase/dehydratase family

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
3 bound ligands:
Ligand UPG 1 x UPG
Ligand EDO 2 x EDO
Ligand GDU 2 x GDU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 51.347Å b: 76.851Å c: 80.163Å
α: 90° β: 91.81° γ: 90°
R-values:
R R work R free
0.188 0.186 0.212
Expression system: Mycolicibacterium smegmatis

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