› 8dr9

X-ray diffraction
1.5Å resolution

Crystal structure of human ALDH2 in complex with NAD+ and PEG MME 550

Released:
DOI: 10.2210/pdb8dr9/pdb
PDB entry 8dr9 coloured by chain, front view.
PDB entry 8dr9 coloured by chain, side view.
PDB entry 8dr9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xu SY, Weng JK

Function and Biology Details

Reaction catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 501 amino acids
Theoretical weight: 54.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05091 (Residues: 18-517; Coverage: 97%)
Gene names: ALDH2, ALDM
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
3 bound ligands:
Ligand CIT 2 x CIT
Ligand NA 2 x NA
Ligand 1PE 9 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P4122
Unit cell:
a: 119.961Å b: 119.961Å c: 135.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.137 0.136 0.157
Expression system: Escherichia coli BL21(DE3)

Quick links