› 8e5q

X-ray diffraction
1.33Å resolution

Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150303 Complex

Released:
DOI: 10.2210/pdb8e5q/pdb
PDB entry 8e5q coloured by chain, front view.
PDB entry 8e5q coloured by chain, side view.
PDB entry 8e5q coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.
Alwan SN, Taylor AB, Rhodes J, Tidwell M, McHardy SF, LoVerde PT
OpenAccess logo PLoS Pathog 19 e1011018 (2023)
PMID: 37428793

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase oxamniquine resistance protein Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.98 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G4VLE5 (Residues: 1-257; Coverage: 100%)
Gene names: SULT-OR, Smp_089320
Sequence domains: Sulfotransferase domain

Ligands and Environments

2 bound ligands:
Ligand UMI 1 x UMI
Ligand A3P 1 x A3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 46.769Å b: 58.486Å c: 90.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.217
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Progress interrogating TRPMPZQ as the target of praziquantel.
Marchant JS. (2024)
2 other articles