› 8faw

X-ray diffraction
2.16Å resolution

Structure of Hemagglutinin from Influenza A/Victoria/22/2020 in complex with LSTC

Released:
DOI: 10.2210/pdb8faw/pdb
PDB entry 8faw coloured by chain, front view.
PDB entry 8faw coloured by chain, side view.
PDB entry 8faw coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin.
Lei R, Liang W, Ouyang WO, Hernandez Garcia A, Kikuchi C, Wang S, McBride R, Tan TJC, Sun Y, Chen C, Graham CS, Rodriguez LA, Shen IR, Choi D, Bruzzone R, Paulson JC, Nair SK, Mok CKP, Wu NC
OpenAccess logo Nat Commun 15 5175 (2024)
PMID: 38890325

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-498483 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 492 amino acids
Theoretical weight: 55.41 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A6M4ZXR4 (Residues: 27-518; Coverage: 87%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BGC, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: R32
Unit cell:
a: 100.349Å b: 100.349Å c: 395.503Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.235
Expression system: Trichoplusia ni

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