› 8fdm

X-ray diffraction
1.91Å resolution

Human Hemoglobin in Complex with Nitrosomethane

Released:
DOI: 10.2210/pdb8fdm/pdb
PDB entry 8fdm coloured by chain, front view.
PDB entry 8fdm coloured by chain, side view.
PDB entry 8fdm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin.
Powell SM, Wang B, Herrera VE, Prather KY, Nguyen NT, Abucayon EG, Thomas LM, Safo MK, Richter-Addo GB
J Inorg Biochem 246 112304 (2023)
PMID: 37406385

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin

Ligands and Environments

5 bound ligands:
Ligand HEM 4 x HEM
Ligand GOL 5 x GOL
Ligand MBN 2 x MBN
Ligand NSM 2 x NSM
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-002
Spacegroup: P41
Unit cell:
a: 53.458Å b: 53.458Å c: 191.375Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.253

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