8kcu

Electron Microscopy
2.7Å resolution

Cryo-EM structure of human gamma-secretase in complex with MK-0752

Released:
Source organism: Homo sapiens
Entry authors: Guo X, Li H, Kai U, Yan C, Lei J, Zhou R, Shi Y
Related structures: EMD-37110

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-156020 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Presenilin-1 Chain: B
Molecule details ›
Chain: B
Length: 467 amino acids
Theoretical weight: 52.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P49768 (Residues: 1-467; Coverage: 100%)
Gene names: AD3, PS1, PSEN1, PSNL1
Sequence domains: Presenilin
Nicastrin Chain: A
Molecule details ›
Chain: A
Length: 701 amino acids
Theoretical weight: 77.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92542 (Residues: 1-701; Coverage: 99%)
Gene names: KIAA0253, NCSTN, UNQ1874/PRO4317
Sequence domains:
Gamma-secretase subunit APH-1A Chain: C
Gamma-secretase subunit PEN-2 Chain: D

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-37110
Expression system: Homo sapiens