› 8owa

X-ray diffraction
2.85Å resolution

SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-4

Released:
DOI: 10.2210/pdb8owa/pdb
PDB entry 8owa coloured by chain, front view.
PDB entry 8owa coloured by chain, side view.
PDB entry 8owa coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Entry authors: Hjorth-Jensen SJ, Konrad DB, Quistgaard EMH, Hansen LC, Novak A, Chu H, Jurasek M, Zimmermann T, Andersen JL, Baran PS, Nissen P, Trauner D

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 991 amino acids
Theoretical weight: 109.3 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-991; Coverage: 99%)
Gene name: ATP2A1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ACE 1 x ACE
Ligand VUK 1 x VUK
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P41212
Unit cell:
a: 71.31Å b: 71.31Å c: 586.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.243 0.279

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