8q6r

X-ray diffraction
1.9Å resolution

Structure of complement FP in complex with the TPP-3077 VHH

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-276186 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
The properdin specific VHH TPP-3077 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 13.8 KDa
Source organism: Lama glama
Expression system: Homo sapiens
Properdin Chains: C, E
Molecule details ›
Chains: C, E
Length: 108 amino acids
Theoretical weight: 11.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 28-135; Coverage: 24%)
Gene names: CFP, PFC
Sequence domains:
Properdin Chains: D, F
Molecule details ›
Chains: D, F
Length: 221 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 256-469; Coverage: 48%)
Gene names: CFP, PFC
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: FUC, BGC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P21
Unit cell:
a: 79.21Å b: 63.701Å c: 119.249Å
α: 90° β: 103.752° γ: 90°
R-values:
R R work R free
0.203 0.202 0.238
Expression system: Homo sapiens