› 8qke

X-ray diffraction
1.5Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241847 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
subtilisin Chains: A, B
Molecule details ›
Chains: A, B
Length: 631 amino acids
Theoretical weight: 69.89 KDa
Source organism: Plasmodium vivax
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: E6Y8B9 (Residues: 26-630; Coverage: 100%)
Gene names: PVC01_100035100, PVT01_100029100, PVW1_100050600, sub1
Sequence domains:
Peptidomimetic Inhibitor (MH-13) Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 629 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand NAG 1 x NAG
Ligand SO4 2 x SO4
1 modified residue:
Ligand 5XU 2 x 5XU

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P1
Unit cell:
a: 53.02Å b: 54.71Å c: 69.14Å
α: 69.39° β: 78.52° γ: 75.02°
R-values:
R R work R free
0.21 0.209 0.226
Expression systems:
  • Drosophila melanogaster
  • Not provided

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