› 8qxl

Electron Microscopy
2.82Å resolution

Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed

Released:
DOI: 10.2210/pdb8qxl/pdb
PDB entry 8qxl coloured by chain, front view.
PDB entry 8qxl coloured by chain, side view.
PDB entry 8qxl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun 15 3775 (2024)
PMID: 38710701
Related structures: EMD-18731

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 626 amino acids
Theoretical weight: 72.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 1-626; Coverage: 100%)
Gene names: MOP5, SAMHD1
Sequence domains:

Ligands and Environments

7 bound ligands:
Ligand GTP 4 x GTP
Ligand FE 4 x FE
Ligand MG 10 x MG
Ligand DCZ 2 x DCZ
Ligand 3PO 2 x 3PO
Ligand DTP 4 x DTP
Ligand DCP 2 x DCP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.82Å
Relevant EMDB volumes: EMD-18731
Expression system: Escherichia coli

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