› 8sjy

Electron crystallography
2.35Å resolution

Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (1SM:2Chol)

Released:
DOI: 10.2210/pdb8sjy/pdb
PDB entry 8sjy coloured by chain, front view.
PDB entry 8sjy coloured by chain, side view.
PDB entry 8sjy coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts.
Chiu PL, Orjuela JD, de Groot BL, Aponte Santamaría C, Walz T
Elife 12 (2024)
PMID: 39222068

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lens fiber major intrinsic protein Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 28.28 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: Q6J8I9 (Residues: 1-263; Coverage: 100%)
Gene names: AQP0, MIP
Sequence domains: Major intrinsic protein

Ligands and Environments

2 bound ligands:
Ligand HWP 5 x HWP
Ligand CLR 4 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.35Å

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