› 8vbw

X-ray diffraction
2.3Å resolution

Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Ertapenem) inhibited form

Released:
DOI: 10.2210/pdb8vbw/pdb
PDB entry 8vbw coloured by chain, front view.
PDB entry 8vbw coloured by chain, side view.
PDB entry 8vbw coloured by chain, top view.
Source organism: Staphylococcaceae bacterium
Primary publication:
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1.
Bon CG, Grigg JC, Lee J, Robb CS, Caveney NA, Eltis LD, Strynadka NCJ
J Struct Biol 216 108086 (2024)
PMID: 38527711

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173476 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PASTA domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 595 amino acids
Theoretical weight: 66.64 KDa
Source organism: Staphylococcaceae bacterium
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2FZ94 (Residues: 39-608; Coverage: 77%)
Gene name: SAOUHSC_01145
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 1RG 2 x 1RG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: C2
Unit cell:
a: 183.399Å b: 72.717Å c: 90.111Å
α: 90° β: 103.47° γ: 90°
R-values:
R R work R free
0.194 0.192 0.232
Expression system: Escherichia coli BL21(DE3)

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