9bko

X-ray diffraction
1.44Å resolution

DHODH in complex with Ligand 26

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
(S)-dihydroorotate + a quinone = orotate + a quinol
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-169672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroorotate dehydrogenase (quinone), mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 39.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 30-395; Coverage: 93%)
Gene name: DHODH
Sequence domains: Dihydroorotate dehydrogenase

Ligands and Environments


Cofactor: Ligand FMN 1 x FMN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 90.781Å b: 90.781Å c: 122.616Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.142 0.17
Expression system: Escherichia coli