› 9eo4

Electron Microscopy
2.66Å resolution

Outward-open structure of human dopamine transporter bound to cocaine

Released:
DOI: 10.2210/pdb9eo4/pdb
PDB entry 9eo4 coloured by chain, front view.
PDB entry 9eo4 coloured by chain, side view.
PDB entry 9eo4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human dopamine transporter in complex with cocaine.
Nielsen JC, Salomon K, Kalenderoglou IE, Bargmeyer S, Pape T, Shahsavar A, Loland CJ
Nature (2024)
PMID: 39112703
Related structures: EMD-19845

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent dopamine transporter Chain: B
Molecule details ›
Chain: B
Length: 660 amino acids
Theoretical weight: 72.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01959 (Residues: 1-620; Coverage: 100%)
Gene names: DAT1, SLC6A3
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

5 bound ligands:
Ligand CLR 3 x CLR
Ligand Y01 1 x Y01
Ligand NA 1 x NA
Ligand CL 1 x CL
Ligand COC 1 x COC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.66Å
Relevant EMDB volumes: EMD-19845
Expression system: Homo sapiens

Quick links