- Display observed secondary structure variance per amino acid residue
LINE-1 retrotransposable element ORF2 protein
Homo sapiens (Human)
O00370go to UniProt
Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (PubMed:7516468, PubMed:9140393). Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (PubMed:17626046, PubMed:34554261, PubMed:8945517). Cleaves DNA in AT-rich regions ... [show more]go to UniProt
Representative structures for UniProt O00370
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PDB chain shown: 7n8s A go to PDBe
UniProt residues 1 - 238
Coverage: 18%