- Display observed secondary structure variance per amino acid residue
Toll-like receptor 3
Homo sapiens (Human)
O15455go to UniProt
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory responsego to UniProt
Representative structure for UniProt O15455
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PDB chain shown: 7c76 A go to PDBe
UniProt residues 1 - 904
Coverage: 76%