Muscarinic toxin 1

Organism:

Dendroaspis angusticeps (Eastern green mamba)

Uniprot:
Biological function:

Shows a non-competitive interaction with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC(50)=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B), and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to M1 (CHRM1) muscarinic acetylcholine receptors, probably by interacting with the orthosteric site (PubMed:12488533, PubMed:24793485, PubMed:7778123). Also reveals a slightly weaker effect at M3 (CHRM3) ... [show more]go to UniProt


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PDB 4do8 chain B (observed residues)
PDB 4do8 chain B (observed residues)

PDB chain shown: 4do8 B go to PDBe

UniProt residues 1 - 66

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3
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1
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6
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13
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