- Display observed secondary structure variance per amino acid residue
Glypican-3
Gpc3
Mus musculus (Mouse)
Q8CFZ4go to UniProt
Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (PubMed:18477453, PubMed:23665349). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation ( [show more]go to UniProt
Representative structure for UniProt Q8CFZ4
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PDB chain shown: 7zav A go to PDBe
UniProt residues 31 - 482
Coverage: 61%
Processed Proteins (2):
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UniProt range of representative PDB 7zav chain A: 31 - 348
UniProt range of representative PDB 7zav chain A: 382 - 482