Homeobox protein NANOG

Gene:

NANOG

Organism:

Homo sapiens (Human)

Uniprot:
Biological function:

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a ... [show more]go to UniProt


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Model 1 / 20
 
PDB 2kt0 chain A (observed residues)
PDB 2kt0 chain A (observed residues)

PDB chain shown: 2kt0 A go to PDBe

UniProt residues 75 - 157

Coverage: 27%

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2
Structures

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Ligands


1
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22
Publications

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