Uniprot accession / id : B3KR14  OR   Uniprot accession / id : P51178  OR   Uniprot accession / id : E2QX57  OR   Uniprot accession / id : P10895  OR   Uniprot accession / id : Q8R3B1  OR   Uniprot accession / id : P10688  OR   Uniprot accession / id : A7MD68  OR   Uniprot accession / id : Q7ZU40  OR   Uniprot accession / id : Q75IL8
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Entry Information
Entry status  (1)
REL
(11)
 
Experimental methods  (1)
X-ray diffraction
(11)
 
Authors  (15)
Essen LO
(10)
Williams RL
(10)
Essen L-O
(8)
Katan M
(8)
Perisic O
(8)
Roberts MF
(4)
Wu Y
(4)
Lynch DE
(3)
Grobler JA
(2)
Hurley JH
(2)
Cheung R
(1)
Ferguson KM
(1)
Lemmon MA
(1)
Schlessinger J
(1)
Sigler PB
(1)
 
Homo / hetero assembly  (1)
homo
(11)
 
Assembly composition  (1)
protein structure
(11)
 
Assembly polymer count  (1)
monomer
(11)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(6)
2.5 - 3
(4)
 
Release year distribution
1995 - 2000
(11)
 
Journal  (4)
Biochemistry
(7)
Nat Struct Biol
(2)
Cell
(1)
Nature
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(11)
 
Organism name  (1)
Rattus norvegicus
(11)
 
Molecule name  (6)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
(11)
PLC-III
(11)
PLC-delta-1
(11)
Phosphoinositide phospholipase C-delta-1
(11)
Phospholipase C-III
(11)
Phospholipase C-delta-1
(11)
 
Molecule type  (1)
Protein
(11)
 
Gene names  (1)
Plcd1
(11)
 
Interacting ligands  (9)
ACT : ACETATE ION
(8)
CA : CALCIUM ION
(5)
I3P : D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
(2)
BA : BARIUM ION
(1)
CIP : INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHATE
(1)
I2P : D-MYO-INOSITOL-2,4,5-TRIPHOSPHATE
(1)
IP2 : D-MYO-INOSITOL-4,5-BISPHOSPHATE
(1)
LA : LANTHANUM (III) ION
(1)
SM : SAMARIUM (III) ION
(1)
 
Function and Biology
EC number / name  (1)
3.1.4.11 : Phosphoinositide phospholipase C
(11)
 
Biological function  (3)
calcium ion binding
(10)
phosphatidylinositol-4,5-bisphosphate phospholipase C activity
(10)
phosphoric diester hydrolase activity
(10)
 
Biological process  (3)
intracellular signal transduction
(11)
lipid metabolic process
(10)
signal transduction
(10)
 
Sequence and Structure classification
SCOP fold  (4)
C2 domain-like
(10)
EF Hand-like
(10)
TIM beta/alpha-barrel
(10)
PH domain-like barrel
(1)
 
SCOP family  (4)
EF-hand modules in multidomain proteins
(10)
Mammalian PLC
(10)
PLC-like (P variant)
(10)
Pleckstrin-homology domain (PH domain)
(1)
 
CATH class  (3)
Mainly Beta
(11)
Alpha Beta
(10)
Mainly Alpha
(10)
 
CATH topology  (4)
Immunoglobulin-like
(10)
Recoverin; domain 1
(10)
TIM Barrel
(10)
PH-domain like
(1)
 
Pfam accession / name  (5)
PF00168 : C2
(10)
PF00387 : PI-PLC-Y
(10)
PF00388 : PI-PLC-X
(10)
PF09279 : EF-hand_like
(10)
PF16457 : PH_12
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 11
Entries 1 to 10 of 11
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1mai
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE
Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB
Cell (1995) [PMID: 8521504  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: I3P    I3P   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
1.9Å resolution
Released: 8 Nov 1996
DOI: 10.2210/pdb1mai  
Model geometry
Fit model/data
Data not deposited
1mai
1mai
1mai
1djg
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9062102  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: LA    ACT    LA    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.6Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb1djg  
Model geometry
Fit model/data
Data not deposited
1djg
1djg
1djg
1djz
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-4,5-BISPHOSPHATE
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9048554  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: IP2    ACT    CA    IP2    CA    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.95Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb1djz  
Model geometry
Fit model/data
1djz
1djz
1djz
1dji
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH CALCIUM
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9062102  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: ACT    CA    CA    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.5Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb1dji  
Model geometry
Fit model/data
1dji
1dji
1dji
1djx
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9048554  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: ACT    CA    I3P    CA    I3P    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.3Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb1djx  
Model geometry
Fit model/data
1djx
1djx
1djx
1djh
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9062102  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: ACT    BA    BA    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.5Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb1djh  
Model geometry
Fit model/data
1djh
1djh
1djh
1djw
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE
Essen L-O, Perisic O, Williams RL
Biochemistry (1997) [PMID: 9048554  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: ACT    CA    CIP    CA    CIP    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.45Å resolution
Released: 23 Jul 1997
DOI: 10.2210/pdb1djw  
Model geometry
Fit model/data
1djw
1djw
1djw
1qas
1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1
Grobler JA, Hurley JH
Nat Struct Biol (1996) [PMID: 8784353  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.4Å resolution
Released: 12 Feb 1997
DOI: 10.2210/pdb1qas  
Model geometry
Fit model/data
Data not deposited
1qas
1qas
1qas
1qat
1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA COMPLEX WITH SAMARIUM (III) CHLORIDE
Grobler JA, Hurley JH
Nat Struct Biol (1996) [PMID: 8784353  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: SM    SM   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
3Å resolution
Released: 12 Feb 1997
DOI: 10.2210/pdb1qat  
Model geometry
Fit model/data
Data not deposited
1qat
1qat
1qat
2isd
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT
Essen L-O, Perisic O, Williams RL
Nature (1996) [PMID: 8602259  ]
Source organism: Rattus norvegicus  
Assembly composition: protein only structure
Bound ligands: ACT    ACT   
Assembly name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145423 (Preferred)   search this ID
PDBe-KB: P10688   
X-ray diffraction
2.5Å resolution
Released: 7 Jul 1997
DOI: 10.2210/pdb2isd  
Model geometry
Fit model/data
Data not deposited
2isd
2isd
2isd
Entries 1 to 10 of 11
Entries 1 to 10 of 11