Uniprot accession / id : D2JYI1  OR   Uniprot accession / id : P37173  OR   Uniprot accession / id : Q90999  OR   Uniprot accession / id : Q58EQ1
 
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Entry Information
Entry status  (1)
REL
(23)
 
Experimental methods  (4)
X-ray diffraction
(17)
Electron Microscopy
(3)
Solution NMR
(2)
Electron crystallography
(1)
 
Authors  (152)
Hinck AP
(12)
Hinck CS
(9)
Taylor AB
(7)
Ruzanov M
(5)
Sheriff S
(5)
Tebben AJ
(5)
Zhang L
(5)
Bernard DJ
(4)
Byeon CH
(4)
Cherepanov P
(4)
Coleman JA
(4)
Conway IO
(4)
Gao M
(4)
Hill CS
(4)
Ishima R
(4)
Kiefer SE
(4)
Kim K
(4)
Kopcho LM
(4)
Krzysiak T
(4)
Lin YF
(4)
Lopez-Casillas F
(4)
Lu H
(4)
López-Casillas F
(4)
Newitt JA
(4)
Punch E
(4)
Wieteska L
(4)
Wieteska Ł
(4)
Xie D
(4)
Yan C
(4)
Calero G
(2)
Deep S
(2)
Forest KT
(2)
Hart PJ
(2)
Kiessling LL
(2)
Kim SK
(2)
Radaev S
(2)
Shu Z
(2)
Sun PD
(2)
Wangkanont K
(2)
Adachi T
(1)
Allen A
(1)
Almo S
(1)
Augustine-Rauch K
(1)
Baker D
(1)
Barnes CO
(1)
Barnett JV
(1)
Barron L
(1)
Bera AK
(1)
Boesen CC
(1)
Borzilleri RM
(1)
Brothers M
(1)
Brown CB
(1)
Callero G
(1)
Cano KE
(1)
Cao L
(1)
Carter L
(1)
Cascio D
(1)
Cheng W
(1)
Conventry B
(1)
Demeler B
(1)
Doi S
(1)
Donnell AF
(1)
Du S
(1)
Edman N
(1)
Eisenberg D
(1)
Fan Y
(1)
Fargnoli J
(1)
Fereshteh MP
(1)
Fink BE
(1)
Garrett S
(1)
Gerben SR
(1)
Ghosh A
(1)
Gonen T
(1)
Goreshnik I
(1)
Groppe J
(1)
Halabiya SF
(1)
Hart MJ
(1)
Hattne J
(1)
Heine P
(1)
Hicks DR
(1)
Ho CP
(1)
Huang B
(1)
Huang T
(1)
Ishikawa T
(1)
Iskra B
(1)
Ju C
(1)
Kim CJ
(1)
Kim S
(1)
Kitao Y
(1)
Kodali R
(1)
Krezel AM
(1)
Lafer EM
(1)
Leal B
(1)
Lee DS
(1)
Li Z
(1)
Lippy J
(1)
Lv Z
(1)
Maeda K
(1)
Marlow MS
(1)
Miwa S
(1)
 
More...
 
Homo / hetero assembly  (2)
homo
(13)
hetero
(10)
 
Assembly composition  (2)
protein structure
(13)
protein/protein complex
(10)
 
Assembly polymer count  (5)
monomer
(13)
pentamer
(4)
dimer
(3)
hexamer
(2)
tetramer
(1)
 
Resolution distribution
1.0 - 1.5
(4)
1.5 - 2
(4)
2.0 - 2.5
(6)
2.5 - 3
(4)
3.0 - 3.5
(1)
3.5 - 4
(1)
4.0 - 4.5
(1)
 
Release year distribution
2000 - 2005
(4)
2005 - 2010
(2)
2010 - 2015
(3)
2015 - 2020
(9)
2020 - 2025
(8)
2025 - 2030
(5)
 
Journal  (12)
Acta Crystallogr D Struct Biol
(4)
Nat Commun
(4)
To be published
(4)
ACS Med Chem Lett
(2)
J Biol Chem
(2)
Biochemistry
(1)
J Mol Biol
(1)
Mol Cell
(1)
Nat Methods
(1)
Nat Struct Biol
(1)
Protein Expr Purif
(1)
Structure
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(23)
 
Organism name  (2)
Homo sapiens
(22)
Gallus gallus
(1)
 
Molecule name  (6)
TGF-beta receptor type II
(23)
TGF-beta receptor type-2
(23)
TGF-beta type II receptor
(23)
TGFR-2
(23)
TbetaR-II
(23)
Transforming growth factor-beta receptor type II
(23)
 
Molecule type  (1)
Protein
(23)
 
Gene names  (1)
TGFBR2
(23)
 
Interacting Molecules  (8)
TGF-beta receptor type-1
(4)
Transforming growth factor beta-3
(4)
Transforming growth factor beta-1
(3)
ZP domain-containing protein
(3)
5HCS_TGFBR2_1
(1)
Transforming growth factor beta mimic 6
(1)
Transforming growth factor beta receptor type 3
(1)
Transforming growth factor beta-2
(1)
 
Interacting ligands  (15)
GOL : GLYCEROL
(4)
1PS : 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE
(1)
41D : 3-[2-(2-hydroxyethyl)pyridinium-1-yl]propane-1-sulfonate
(1)
5L4 : 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide
(1)
ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
(1)
CAC : CACODYLATE ION
(1)
CL : CHLORIDE ION
(1)
EDO : 1,2-ETHANEDIOL
(1)
HJF : 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine
(1)
J2V : N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide
(1)
MG : MAGNESIUM ION
(1)
NA : SODIUM ION
(1)
PEG : DI(HYDROXYETHYL)ETHER
(1)
SO4 : SULFATE ION
(1)
STU : STAUROSPORINE
(1)
 
Function and Biology
EC number / name  (1)
2.7.11.30 : Receptor protein serine/threonine kinase
(23)
 
Biological function  (5)
ATP binding
(18)
metal ion binding
(11)
transforming growth factor beta receptor activity, type II
(11)
protein kinase activity
(7)
transmembrane receptor protein serine/threonine kinase activity
(7)
 
Biological process  (2)
protein phosphorylation
(18)
cell surface receptor protein serine/threonine kinase signaling pathway
(7)
 
Biological cell component  (1)
membrane
(18)
 
Sequence and Structure classification
SCOP fold  (1)
Snake toxin-like
(5)
 
SCOP family  (1)
Extracellular domain of cell surface receptors
(5)
 
CATH class  (3)
Mainly Beta
(10)
Alpha Beta
(5)
Mainly Alpha
(5)
 
Representative Structures
Representative Structures
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40%
30%
Entries 1 to 10 of 23
Entries 1 to 10 of 23
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Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents
Nishihata J, Nomura A, Miwa S, Doi S, Adachi T
ACS Med Chem Lett (2021) [PMID: 34055221  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: HJF   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
2.39Å resolution
Released: 16 Jun 2021
Model geometry
Fit model/data
7dv6
7dv6
7dv6
MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution
Weiss SC, de la Cruz MJ, Hattne J, Shi D, Reyes FE, Callero G, Gonen T
Nat Methods (2017) [PMID: 28192420  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Transforming growth factor beta-2 and TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153365 (Preferred)   search this ID
PDBe-KB: P37173    P61812   
Electron crystallography
2.9Å resolution
Released: 26 Apr 2017
Model geometry
Fit model/data
Data not analysed
5ty4
5ty4
5ty4
Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
Hinck AP, Kim S
J Biol Chem (2017) [PMID: 28228478  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173    P61812   
X-ray diffraction
1.876Å resolution
Released: 1 Mar 2017
Model geometry
Fit model/data
5tx4
5tx4
5tx4
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE
Sheriff S
Acta Crystallogr D Struct Biol (2016) [PMID: 27139629  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 5L4    5L4   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
2.42Å resolution
Released: 11 May 2016
Model geometry
Fit model/data
5e91
5e91
5e91
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH AMPPNP
Sheriff S
Acta Crystallogr D Struct Biol (2016) [PMID: 27139629  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ANP    MG    ANP    MG   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
2.08Å resolution
Released: 11 May 2016
Model geometry
Fit model/data
5e92
5e92
5e92
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE
Sheriff S
Acta Crystallogr D Struct Biol (2016) [PMID: 27139629  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: STU   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
2.05Å resolution
Released: 11 May 2016
Model geometry
Fit model/data
5e8y
5e8y
5e8y
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A)
Sheriff S
Acta Crystallogr D Struct Biol (2016) [PMID: 27139629  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: GOL   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
1.69Å resolution
Released: 11 May 2016
Model geometry
Fit model/data
5e8v
5e8v
5e8v
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE
Sheriff S
ACS Med Chem Lett (2018) [PMID: 30429955  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    GOL    J2V    J2V    MG   
Assembly name: TGF-beta receptor type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-153364 (Preferred)   search this ID
PDBe-KB: P37173   
X-ray diffraction
1.57Å resolution
Released: 31 Oct 2018
Model geometry
Fit model/data
5qin
5qin
5qin
Betaglycan Orphan Domain (ratBGo) in complex with TGF-b1 and extracellular domain of TGFBRII
Wieteska L, Cherepanov P, Punch E, Hinck AP, Hill CS
Nat Commun (2025) [PMID: 40011426  ]
Assembly composition: protein/protein complex
Assembly name: TGF-beta-1 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-289452 (Preferred)   search this ID
PDBe-KB: P37173    P01137    P26342   
Electron Microscopy
3.4Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
Data not analysed
9fdy
9fdy
9fdy
Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-B3 and extracellular domains of TGFBRI and TGFBRII
Wieteska L, Coleman JA, Hinck AP
Nat Commun (2025) [PMID: 40011426  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-288540 (Preferred)   search this ID
PDBe-KB: P37173    P10600    P36897    A0A0H3UK16   
Electron Microscopy
4.1Å resolution
Released: 12 Mar 2025
Model geometry
Fit model/data
Data not analysed
9fk5
9fk5
9fk5
Entries 1 to 10 of 23
Entries 1 to 10 of 23