Filter by :
Entry Information
Entry status
(1)
Experimental methods
(4)
X-ray diffraction
(17)
Electron Microscopy
(3)
Solution NMR
(2)
Electron crystallography
(1)
Authors
(152)
Hinck AP
(12)
Hinck CS
(9)
Taylor AB
(7)
Ruzanov M
(5)
Sheriff S
(5)
Tebben AJ
(5)
Zhang L
(5)
Bernard DJ
(4)
Byeon CH
(4)
Cherepanov P
(4)
Coleman JA
(4)
Conway IO
(4)
Gao M
(4)
Hill CS
(4)
Ishima R
(4)
Kiefer SE
(4)
Kim K
(4)
Kopcho LM
(4)
Krzysiak T
(4)
Lin YF
(4)
Lopez-Casillas F
(4)
Lu H
(4)
López-Casillas F
(4)
Newitt JA
(4)
Punch E
(4)
Wieteska L
(4)
Wieteska Ł
(4)
Xie D
(4)
Yan C
(4)
Calero G
(2)
Deep S
(2)
Forest KT
(2)
Hart PJ
(2)
Kiessling LL
(2)
Kim SK
(2)
Radaev S
(2)
Shu Z
(2)
Sun PD
(2)
Wangkanont K
(2)
Adachi T
(1)
Allen A
(1)
Almo S
(1)
Augustine-Rauch K
(1)
Baker D
(1)
Barnes CO
(1)
Barnett JV
(1)
Barron L
(1)
Bera AK
(1)
Boesen CC
(1)
Borzilleri RM
(1)
Brothers M
(1)
Brown CB
(1)
Callero G
(1)
Cano KE
(1)
Cao L
(1)
Carter L
(1)
Cascio D
(1)
Cheng W
(1)
Conventry B
(1)
Demeler B
(1)
Doi S
(1)
Donnell AF
(1)
Du S
(1)
Edman N
(1)
Eisenberg D
(1)
Fan Y
(1)
Fargnoli J
(1)
Fereshteh MP
(1)
Fink BE
(1)
Garrett S
(1)
Gerben SR
(1)
Ghosh A
(1)
Gonen T
(1)
Goreshnik I
(1)
Groppe J
(1)
Halabiya SF
(1)
Hart MJ
(1)
Hattne J
(1)
Heine P
(1)
Hicks DR
(1)
Ho CP
(1)
Huang B
(1)
Huang T
(1)
Ishikawa T
(1)
Iskra B
(1)
Ju C
(1)
Kim CJ
(1)
Kim S
(1)
Kitao Y
(1)
Kodali R
(1)
Krezel AM
(1)
Lafer EM
(1)
Leal B
(1)
Lee DS
(1)
Li Z
(1)
Lippy J
(1)
Lv Z
(1)
Maeda K
(1)
Marlow MS
(1)
Miwa S
(1)
More...
Homo / hetero assembly
(2)
homo
(13)
hetero
(10)
Assembly composition
(2)
protein structure
(13)
protein/protein complex
(10)
Assembly polymer count
(5)
monomer
(13)
pentamer
(4)
dimer
(3)
hexamer
(2)
tetramer
(1)
Resolution distribution
1.0 - 1.5
(4)
1.5 - 2
(4)
2.0 - 2.5
(6)
2.5 - 3
(4)
3.0 - 3.5
(1)
3.5 - 4
(1)
4.0 - 4.5
(1)
Release year distribution
2000 - 2005
(4)
2005 - 2010
(2)
2010 - 2015
(3)
2015 - 2020
(9)
2020 - 2025
(8)
2025 - 2030
(5)
Journal
(12)
Acta Crystallogr D Struct Biol
(4)
Nat Commun
(4)
To be published
(4)
ACS Med Chem Lett
(2)
J Biol Chem
(2)
Biochemistry
(1)
J Mol Biol
(1)
Mol Cell
(1)
Nat Methods
(1)
Nat Struct Biol
(1)
Protein Expr Purif
(1)
Structure
(1)
Macromolecules
Organism superkingdom
(1)
Eukaryota
(23)
Organism name
(2)
Homo sapiens
(22)
Gallus gallus
(1)
Molecule name
(6)
TGF-beta receptor type II
(23)
TGF-beta receptor type-2
(23)
TGF-beta type II receptor
(23)
TGFR-2
(23)
TbetaR-II
(23)
Transforming growth factor-beta receptor type II
(23)
Molecule type
(1)
Protein
(23)
Gene names
(1)
TGFBR2
(23)
Interacting Molecules
(8)
TGF-beta receptor type-1
(4)
Transforming growth factor beta-3
(4)
Transforming growth factor beta-1
(3)
ZP domain-containing protein
(3)
5HCS_TGFBR2_1
(1)
Transforming growth factor beta mimic 6
(1)
Transforming growth factor beta receptor type 3
(1)
Transforming growth factor beta-2
(1)
Interacting ligands
(15)
GOL : GLYCEROL
(4)
1PS : 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE
(1)
41D : 3-[2-(2-hydroxyethyl)pyridinium-1-yl]propane-1-sulfonate
(1)
5L4 : 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide
(1)
ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
(1)
CAC : CACODYLATE ION
(1)
CL : CHLORIDE ION
(1)
EDO : 1,2-ETHANEDIOL
(1)
HJF : 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine
(1)
J2V : N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide
(1)
MG : MAGNESIUM ION
(1)
NA : SODIUM ION
(1)
PEG : DI(HYDROXYETHYL)ETHER
(1)
SO4 : SULFATE ION
(1)
STU : STAUROSPORINE
(1)
Function and Biology
EC number / name
(1)
2.7.11.30 : Receptor protein serine/threonine kinase
(23)
Biological function
(5)
ATP binding
(18)
metal ion binding
(11)
transforming growth factor beta receptor activity, type II
(11)
protein kinase activity
(7)
transmembrane receptor protein serine/threonine kinase activity
(7)
Biological process
(2)
protein phosphorylation
(18)
cell surface receptor protein serine/threonine kinase signaling pathway
(7)
Biological cell component
(1)
membrane
(18)
Sequence and Structure classification
SCOP fold
(1)
Snake toxin-like
(5)
SCOP family
(1)
Extracellular domain of cell surface receptors
(5)
CATH class
(3)
Mainly Beta
(10)
Alpha Beta
(5)
Mainly Alpha
(5)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 23
Select all entries on this page
Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents
Nishihata J, Nomura A, Miwa S, Doi S, Adachi T
ACS Med Chem Lett
(2021)
[PMID: 34055221 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
HJF
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution
Weiss SC, de la Cruz MJ, Hattne J, Shi D, Reyes FE, Callero G, Gonen T
Nat Methods
(2017)
[PMID: 28192420 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Transforming growth factor beta-2 and TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153365 (Preferred)
search this ID
Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
Hinck AP, Kim S
J Biol Chem
(2017)
[PMID: 28228478 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE
Sheriff S
Acta Crystallogr D Struct Biol
(2016)
[PMID: 27139629 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH AMPPNP
Sheriff S
Acta Crystallogr D Struct Biol
(2016)
[PMID: 27139629 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE
Sheriff S
Acta Crystallogr D Struct Biol
(2016)
[PMID: 27139629 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
STU
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A)
Sheriff S
Acta Crystallogr D Struct Biol
(2016)
[PMID: 27139629 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Bound ligands:
GOL
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE
Sheriff S
ACS Med Chem Lett
(2018)
[PMID: 30429955 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
TGF-beta receptor type-2
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-153364 (Preferred)
search this ID

Betaglycan Orphan Domain (ratBGo) in complex with TGF-b1 and extracellular domain of TGFBRII
Wieteska L, Cherepanov P, Punch E, Hinck AP, Hill CS
Nat Commun
(2025)
[PMID: 40011426 ]
Source organisms: Rattus norvegicus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
TGF-beta-1 complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-289452 (Preferred)
search this ID
Zebrafish Betaglycan Orphan Domain (zfBGo) in complex with TGF-B3 and extracellular domains of TGFBRI and TGFBRII
Wieteska L, Coleman JA, Hinck AP
Nat Commun
(2025)
[PMID: 40011426 ]
Source organisms: Danio rerio , Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-288540 (Preferred)
search this ID
Entries 1 to 10 of 23