Uniprot accession / id : O08734  OR   Uniprot accession / id : Q16611
 
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Entry Information
Entry status  (1)
REL
(54)
 
Experimental methods  (2)
X-ray diffraction
(48)
Solution NMR
(6)
 
Authors  (268)
Colman PM
(28)
Czabotar PE
(25)
Brouwer JM
(20)
Dewson G
(20)
Smith BJ
(17)
Cowan AD
(15)
Bernardini JP
(13)
Fairlie WD
(13)
Lee EF
(13)
Tan IK
(13)
Robin AY
(11)
Wardak AZ
(10)
Birkinshaw RW
(9)
van Delft MF
(9)
Kluck RM
(8)
Lessene G
(8)
Reid GE
(8)
Roy MJ
(8)
Wardak A
(8)
Call MJ
(7)
Gulbis JM
(7)
Lan P
(7)
Reljic B
(7)
Sandow JJ
(7)
Sleebs BE
(7)
Smith NA
(7)
Webb AI
(7)
Kapp EA
(6)
Moldoveanu T
(6)
Murphy JM
(6)
Rustam YH
(6)
Uren RT
(6)
Kvansakul M
(5)
Miller MS
(5)
Chappaz S
(4)
Debrincat MA
(4)
Evangelista M
(4)
Grace CR
(4)
Kile BT
(4)
Lane RM
(4)
Aggarwal A
(3)
Aguilar F
(3)
Bouillet P
(3)
Chen Y
(3)
Gehring K
(3)
Ghose D
(3)
Grabow S
(3)
Grant RA
(3)
Gray DH
(3)
Guibao CD
(3)
Hockings C
(3)
Huang DCS
(3)
Iyer S
(3)
Keating AE
(3)
Lio D
(3)
McNamara DE
(3)
Pettikiriarachchi A
(3)
Sarosiek KA
(3)
Seetharaman J
(3)
Singh G
(3)
Su BG
(3)
Swanson S
(3)
Vaithiyalingam S
(3)
Waddell MB
(3)
Wang H
(3)
Witkowski MT
(3)
Yu S
(3)
Barry M
(2)
Bartolo R
(2)
Caria S
(2)
Chen L
(2)
Chen X
(2)
Choi JS
(2)
Gehring KB
(2)
Guo M
(2)
Hagn F
(2)
Haslbeck M
(2)
Huang DC
(2)
Kim SJ
(2)
Ku B
(2)
Lim D
(2)
Liu Q
(2)
Lu X
(2)
Luo C
(2)
Marshall B
(2)
Peng L
(2)
Qu L
(2)
Ruhrnossl F
(2)
Rührnößl F
(2)
Schiller A
(2)
Seo J
(2)
Shah S
(2)
Shi MX
(2)
Shin HC
(2)
Shore G
(2)
Shore GC
(2)
Smyth ST
(2)
Sperl LE
(2)
Tan Z
(2)
Thompson GV
(2)
 
More...
 
Homo / hetero assembly  (2)
hetero
(34)
homo
(20)
 
Assembly composition  (2)
protein/protein complex
(34)
protein structure
(20)
 
Assembly polymer count  (6)
dimer
(33)
tetramer
(12)
monomer
(6)
24-mer
(1)
hexamer
(1)
trimer
(1)
 
Resolution distribution
1.0 - 1.5
(7)
1.5 - 2
(15)
2.0 - 2.5
(17)
2.5 - 3
(6)
3.0 - 3.5
(3)
 
Release year distribution
1995 - 2000
(1)
2005 - 2010
(7)
2010 - 2015
(9)
2015 - 2020
(21)
2020 - 2025
(25)
2025 - 2030
(2)
 
Journal  (22)
Mol Cell
(13)
Nat Struct Mol Biol
(7)
Cell Death Differ
(4)
Structure
(4)
Genes Dev
(3)
Nat Commun
(3)
To be published
(3)
EMBO J
(2)
FEBS J
(2)
Acta Crystallogr D Biol Crystallogr
(1)
Cell Death Dis
(1)
Commun Biol
(1)
J Am Chem Soc
(1)
J Struct Biol
(1)
J Virol
(1)
Nat Chem Biol
(1)
PLoS Biol
(1)
PLoS Pathog
(1)
Proc Natl Acad Sci U S A
(1)
Proteins
(1)
Sci Rep
(1)
Science
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(54)
 
Organism name  (3)
Homo sapiens
(50)
Mus musculus
(4)
Aequorea victoria
(2)
 
Molecule name  (5)
Apoptosis regulator BAK
(54)
Bcl-2 homologous antagonist/killer
(54)
Bcl-2-like protein 7
(50)
Bcl2-L-7
(50)
Green fluorescent protein
(2)
 
Molecule type  (1)
Protein
(54)
 
Gene names  (7)
BAK
(50)
BAK1
(50)
BCL2L7
(50)
CDN1
(50)
Bak
(4)
Bak1
(4)
GFP
(2)
 
Interacting Molecules  (22)
Bcl-2-like protein 11
(6)
Bcl-2-like protein 1
(4)
BH3-interacting domain death agonist p11
(3)
Apoptosis regulator BAX
(2)
Apoptosis regulator OPG045
(2)
Bcl-2-related protein A1
(2)
Induced myeloid leukemia cell differentiation protein Mcl-1
(2)
14G6 Fab heavy chain
(1)
14G6 Fab light chain
(1)
7D10 antibody VH fragment
(1)
7D10 antibody VL fragment
(1)
Apoptosis regulator BHRF1
(1)
Apoptosis regulator DPV022
(1)
Apoptosis regulator M11L
(1)
Bcl-2 Bcl-2 homology region 1-3 domain-containing protein
(1)
Bcl-2 homologous antagonist/killer
(1)
DF2 peptide
(1)
DM2 peptide
(1)
Peroxisomal testis-specific protein 1
(1)
Protein BNIP5
(1)
Ubiquitin
(1)
dF3 peptide
(1)
 
Interacting ligands  (32)
SO4 : SULFATE ION
(9)
EDO : 1,2-ETHANEDIOL
(5)
GOL : GLYCEROL
(4)
ZN : ZINC ION
(4)
PEG : DI(HYDROXYETHYL)ETHER
(3)
CL : CHLORIDE ION
(2)
CU : COPPER (II) ION
(2)
K6G : [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
(2)
MPD : (4S)-2-METHYL-2,4-PENTANEDIOL
(2)
1PG : 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL
(1)
33B : 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}
(1)
8SP : O-[(R)-{[(2R)-2,3-bis(octanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
(1)
ACT : ACETATE ION
(1)
BR : BROMIDE ION
(1)
C8E : (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
(1)
CAC : CACODYLATE ION
(1)
EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
(1)
FMT : FORMIC ACID
(1)
IMD : IMIDAZOLE
(1)
LBN : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
(1)
LMT : DODECYL-BETA-D-MALTOSIDE
(1)
MG : MAGNESIUM ION
(1)
N8E : 3,6,9,12,15-PENTAOXATRICOSAN-1-OL
(1)
NA : SODIUM ION
(1)
NO3 : NITRATE ION
(1)
P33 : 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL
(1)
PEE : 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
(1)
PG0 : 2-(2-METHOXYETHOXY)ETHANOL
(1)
PG8 : 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)
(1)
PGE : TRIETHYLENE GLYCOL
(1)
PO4 : PHOSPHATE ION
(1)
TFA : trifluoroacetic acid
(1)
 
Function and Biology
Biological process  (3)
regulation of apoptotic process
(47)
bioluminescence
(2)
generation of precursor metabolites and energy
(2)
 
Sequence and Structure classification
CATH class  (2)
Mainly Alpha
(9)
Mainly Beta
(2)
 
CATH topology  (2)
Apoptosis Regulator Bcl-x
(9)
Green Fluorescent Protein
(2)
 
Pfam accession / name  (2)
PF00452 : Bcl-2
(38)
PF01353 : GFP
(2)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(47)
MAD
(1)
 
Diffraction radiation source type  (2)
Synchrotron
(46)
Rotating anode
(2)
 
Diffraction source  (18)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(24)
AUSTRALIAN SYNCHROTRON BEAMLINE MX1
(4)
APS BEAMLINE 22-ID
(3)
APS BEAMLINE 24-ID-C
(3)
APS BEAMLINE 17-ID
(1)
APS BEAMLINE 23-ID-B
(1)
ESRF BEAMLINE ID14-2
(1)
NSLS BEAMLINE X29A
(1)
NSLS BEAMLINE X4C
(1)
NSLS BEAMLINE X8C
(1)
NSLS-II BEAMLINE 17-ID-2
(1)
PAL/PLS BEAMLINE 5C (4A)
(1)
PAL/PLS BEAMLINE 7A (6B, 6C1)
(1)
RIGAKU
(1)
RIGAKU MICROMAX-007 HF
(1)
SLS BEAMLINE X06SA
(1)
SSRF BEAMLINE BL02U1
(1)
SSRF BEAMLINE BL17B1
(1)
 
Synchrotron site  (8)
Australian Synchrotron
(28)
APS
(8)
NSLS
(3)
PAL/PLS
(2)
SSRF
(2)
ESRF
(1)
NSLS-II
(1)
SLS
(1)
 
Diffraction detector type  (3)
CCD
(28)
Pixel
(17)
Image plate
(3)
 
Refinement software  (6)
PHENIX
(38)
REFMAC
(7)
CNS
(2)
BUSTER
(1)
BUSTER-TNT
(1)
X-PLOR
(1)
 
NMR
NMR software packages  (9)
TopSpin
(3)
NMRFAM-SPARKY
(2)
Xplor-NIH
(2)
ARIA
(1)
CNS
(1)
CYANA
(1)
CcpNmr Analysis
(1)
NMRPipe
(1)
X-PLOR
(1)
 
NMR Field Strength
500.0 - 600
(4)
600.0 - 700
(4)
700.0 - 800
(2)
800.0 - 900
(4)
900.0 - 1000
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 54
Entries 1 to 10 of 54
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Crystal structure of BAK L100A in complex with activating antibody fragments
Robin YA, Colman PM
Cell Death Differ (2022) [PMID: 35279694  ]
Assembly composition: protein/protein complex
Bound ligands: MPD   
Assembly name: Bcl-2 homologous antagonist/killer and IG-light kappa chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-226227 (Preferred)   search this ID
PDBe-KB: Q16611   
X-ray diffraction
3.1Å resolution
Released: 9 Feb 2022
Model geometry
Fit model/data
7lk4
7lk4
7lk4
Crystal structure of the Mcl-1 in complex with a Short BH3 peptide of BAK
Wang H, Guo M, Wei H, Chen Y
Cell Death Differ (2025) [PMID: 39901037  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Bcl-2 homologous antagonist/killer and Induced myeloid leukemia cell differentiation protein Mcl-1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-286663 (Preferred)   search this ID
PDBe-KB: Q16611    Q07820   
X-ray diffraction
1.914Å resolution
Released: 29 Jan 2025
Model geometry
Fit model/data
8y1z
8y1z
8y1z
Crystal Structure of human BAK in complex with WT BAK BH3 peptide
Singh G, Aggarwal A, Moldoveanu T
Nat Commun (2022) [PMID: 35017502  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: CU    CU    SO4   
Assembly name: Bcl-2 homologous antagonist/killer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-278778 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611   
X-ray diffraction
3.06Å resolution
Released: 12 Jan 2022
Model geometry
Fit model/data
7m5c
7m5c
7m5c
BH3 domain swapped dimer of a BAK fragment
Liu L-K
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    PEG    SO4    EPE   
Assembly name: Bcl-2 homologous antagonist/killer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172524 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611   
X-ray diffraction
2.3Å resolution
Released: 7 Oct 2020
Model geometry
Fit model/data
6odh
6odh
6odh
Bak core latch dimer in complex with Bim-h0-h3Glt
Brouwer JM, Lan P, Lessene G, Colman PM, Czabotar PE
Mol Cell (2017) [PMID: 29149594  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: EDO   
Modified residues: 9R4    9R4   
Assembly name: Bcl-2 homologous antagonist/killer and Bcl-2-like protein 11 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-285905 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611    O43521   
X-ray diffraction
2.489Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5vwx
5vwx
5vwx
Bak in complex with Bim-h3Glg
Brouwer JM, Lan P, Lessene G, Colman PM, Czabotar PE
Mol Cell (2017) [PMID: 29149594  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    MG    EDO   
Modified residues: 9R7    9R7   
Assembly name: Bcl-2 homologous antagonist/killer and Bcl-2-like protein 11 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-285905 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611    O43521   
X-ray diffraction
1.599Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5vx0
5vx0
5vx0
Bcl-xL with mouse Bak BH3 Q75L complex
Fairlie WD, Lee EF, Smith BJ
Genes Dev (2016) [PMID: 27198225  ]
Assembly composition: protein/protein complex
Bound ligands: EDO   
Assembly name: Bcl-2-like protein 1 and Bcl-2 homologous antagonist/killer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126663 (Preferred)   search this ID
PDBe-KB: O08734    Q07817   
X-ray diffraction
2.43Å resolution
Released: 1 Jun 2016
Model geometry
Fit model/data
5fmj
5fmj
5fmj
Bak core latch dimer in complex with Bim-BH3 - Cubic
Brouwer JM, Colman PM, Czabotar PE
Mol Cell (2017) [PMID: 29149594  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: GOL    TFA    TFA    CL    EDO   
Assembly name: Bcl-2 homologous antagonist/killer and Bcl-2-like protein 11 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-285903 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611    O43521   
X-ray diffraction
1.897Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5vwv
5vwv
5vwv
Bak core latch dimer in complex with Bim-h3Pc-RT
Brouwer JM, Colman PM, Czabotar PE
Mol Cell (2017) [PMID: 29149594  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: PO4   
Modified residues: 9R1    9R1   
Assembly name: Bcl-2 homologous antagonist/killer and Bcl-2-like protein 11 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-285905 (Preferred)   search this ID
PDBe-KB: Q16611    Q16611    O43521   
X-ray diffraction
1.555Å resolution
Released: 15 Nov 2017
Model geometry
Fit model/data
5vwy
5vwy
5vwy
Human Bak Q77L
Fairlie WD, Lee EF, Smith BJ
Genes Dev (2016) [PMID: 27198225  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Bcl-2 homologous antagonist/killer (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172524 (Preferred)   search this ID
PDBe-KB: Q16611   
X-ray diffraction
1.491Å resolution
Released: 1 Jun 2016
Model geometry
Fit model/data
5fmi
5fmi
5fmi
...
Entries 1 to 10 of 54
Entries 1 to 10 of 54