Uniprot accession / id : O15392  OR   Uniprot accession / id : Q8I009  OR   Uniprot accession / id : Q6J1J1  OR   Uniprot accession / id : O70201  OR   Uniprot accession / id : Q549P2  OR   Uniprot accession / id : F1NN48  OR   Uniprot accession / id : Q9DDK0  OR   Uniprot accession / id : Q90WU9  OR   Uniprot accession / id : Q9VEM2
 
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Entry Information
Entry status  (1)
REL
(31)
 
Experimental methods  (3)
X-ray diffraction
(29)
Electron Microscopy
(1)
Solution NMR
(1)
 
Authors  (65)
Minor W
(11)
Niedzialkowska E
(11)
Stukenberg PT
(11)
Higgins JM
(7)
Porebski PJ
(7)
Wang F
(7)
Du J
(5)
Funabiki H
(5)
Kelly AE
(5)
Patel DJ
(5)
Adli M
(4)
Barr FA
(4)
Conti E
(4)
Jeyaprakash AA
(4)
Kuscu C
(4)
Liu L
(4)
Mayo Z
(4)
Serena M
(4)
Strahl BD
(4)
Basquin C
(3)
Bastos RN
(3)
Elliott PR
(3)
Jayachandran U
(3)
Bourhis E
(2)
Cochran AG
(2)
Hymowitz SG
(2)
Altieri DC
(1)
Chantalat L
(1)
Chen J
(1)
Chruszcz M
(1)
Chung CW
(1)
Cooper DR
(1)
Dideberg O
(1)
Dutil E
(1)
Ebert J
(1)
Garcia-Bonete MJ
(1)
Gold DB
(1)
Gruneberg U
(1)
Huang H
(1)
Hunter T
(1)
Jakob C
(1)
Jung B
(1)
Kaiser DA
(1)
Katona G
(1)
Klein UR
(1)
Kleman JP
(1)
Li F
(1)
Lindner D
(1)
Liu Z
(1)
Margolis RL
(1)
Matayoshi ED
(1)
Muchmore SW
(1)
Nettesheim D
(1)
Ng SC
(1)
Nigg EA
(1)
Noel JP
(1)
Olejniczak ET
(1)
Roberts E
(1)
Ruza RR
(1)
Skoufias DA
(1)
Sun C
(1)
Verdecia MA
(1)
Wu W
(1)
Zakula D
(1)
Zhang H
(1)
 
Homo / hetero assembly  (2)
hetero
(23)
homo
(8)
 
Assembly composition  (3)
protein/protein complex
(22)
protein structure
(8)
DNA/protein complex
(1)
 
Assembly polymer count  (5)
tetramer
(16)
dimer
(11)
trimer
(2)
monomer
(1)
tridecamer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(1)
2.0 - 2.5
(7)
2.5 - 3
(18)
3.0 - 3.5
(3)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(4)
2005 - 2010
(4)
2010 - 2015
(15)
2015 - 2020
(4)
2020 - 2025
(8)
2025 - 2030
(1)
 
Journal  (10)
Mol Biol Cell
(11)
Structure
(8)
J Cell Biol
(3)
J Biol Chem
(2)
Mol Cell
(2)
Acta Crystallogr A Found Adv
(1)
Biochemistry
(1)
Biorxiv
(1)
Cell
(1)
Nat Struct Biol
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(31)
 
Organism name  (2)
Homo sapiens
(30)
Mus musculus
(1)
 
Molecule name  (4)
Apoptosis inhibitor 4
(31)
Apoptosis inhibitor survivin
(31)
Baculoviral IAP repeat-containing protein 5
(31)
TIAP
(1)
 
Molecule type  (1)
Protein
(31)
 
Gene names  (6)
API4
(30)
BIRC5
(30)
IAP4
(30)
Api4
(1)
Birc5
(1)
Iap4
(1)
 
Interacting Molecules  (13)
Histone H3.1
(13)
Borealin
(7)
Inner centromere protein
(5)
Diablo IAP-binding mitochondrial protein, cleaved form
(2)
DNA (147-MER)
(1)
Histone H2A type 1
(1)
Histone H2B 1.1
(1)
Histone H3
(1)
Histone H3.2
(1)
Histone H4
(1)
N-TERMINAL FRAGMENT OF HISTONE H3
(1)
N-terminal fragment of histone H3
(1)
Shugoshin 1
(1)
 
Interacting ligands  (10)
ZN : ZINC ION
(31)
EDO : 1,2-ETHANEDIOL
(4)
SO4 : SULFATE ION
(3)
PEG : DI(HYDROXYETHYL)ETHER
(2)
PG4 : TETRAETHYLENE GLYCOL
(2)
1PE : PENTAETHYLENE GLYCOL
(1)
ACT : ACETATE ION
(1)
CO : COBALT (II) ION
(1)
MES : 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
(1)
PGE : TRIETHYLENE GLYCOL
(1)
 
Function and Biology
Biological function  (13)
cysteine-type endopeptidase inhibitor activity
(29)
metal ion binding
(29)
microtubule binding
(29)
peptidase inhibitor activity
(29)
protein binding
(29)
enzyme binding
(28)
identical protein binding
(28)
protein-folding chaperone binding
(28)
small GTPase binding
(28)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(1)
protein homodimerization activity
(1)
tubulin binding
(1)
zinc ion binding
(1)
 
Biological process  (29)
apoptotic process
(29)
cell division
(29)
chromosome segregation
(29)
mitotic cell cycle
(29)
mitotic cytokinesis
(29)
mitotic spindle midzone assembly
(29)
mitotic spindle organization
(29)
negative regulation of DNA-templated transcription
(29)
negative regulation of apoptotic process
(29)
positive regulation of attachment of mitotic spindle microtubules to kinetochore
(29)
positive regulation of mitotic cell cycle spindle assembly checkpoint
(29)
positive regulation of mitotic cytokinesis
(29)
positive regulation of mitotic sister chromatid separation
(29)
protein-containing complex localization
(29)
mitotic spindle assembly
(28)
positive regulation of cell population proliferation
(28)
regulation of apoptotic process
(28)
sensory perception of sound
(28)
G2/M transition of mitotic cell cycle
(1)
establishment of chromosome localization
(1)
meiosis I
(1)
microtubule cytoskeleton organization
(1)
mitotic spindle assembly checkpoint signaling
(1)
negative regulation of neuron apoptotic process
(1)
positive regulation of exit from mitosis
(1)
positive regulation of mitotic cell cycle
(1)
regulation of insulin secretion involved in cellular response to glucose stimulus
(1)
regulation of mitotic cell cycle
(1)
regulation of type B pancreatic cell proliferation
(1)
 
Biological cell component  (20)
chromosome
(29)
chromosome passenger complex
(29)
chromosome, centromeric region
(29)
cytoplasm
(29)
cytoskeleton
(29)
cytosol
(29)
kinetochore
(29)
microtubule
(29)
microtubule cytoskeleton
(29)
midbody
(29)
nucleus
(29)
spindle
(29)
survivin complex
(29)
nuclear chromosome
(28)
nucleoplasm
(28)
spindle midzone
(28)
centriole
(1)
cytoplasmic microtubule
(1)
interphase microtubule organizing center
(1)
spindle microtubule
(1)
 
Sequence and Structure classification
SCOP fold  (1)
Inhibitor of apoptosis (IAP) repeat
(7)
 
SCOP family  (1)
Inhibitor of apoptosis (IAP) repeat
(7)
 
CATH class  (1)
Mainly Alpha
(22)
 
CATH topology  (1)
Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
(22)
 
Pfam accession / name  (1)
PF00653 : BIR
(31)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(28)
MAD
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(29)
 
Diffraction source  (17)
APS BEAMLINE 21-ID-G
(5)
APS BEAMLINE 24-ID-E
(3)
SLS BEAMLINE X10SA
(3)
APS BEAMLINE 19-ID
(2)
APS BEAMLINE 21-ID-D
(2)
APS BEAMLINE 21-ID-F
(2)
SSRL BEAMLINE BL9-2
(2)
ALS BEAMLINE 5.0.1
(1)
APS BEAMLINE 17-ID
(1)
APS BEAMLINE 24-ID-C
(1)
DIAMOND BEAMLINE I24
(1)
ESRF BEAMLINE BM14
(1)
ESRF BEAMLINE ID23-1
(1)
ESRF BEAMLINE ID30B
(1)
NSLS BEAMLINE X29A
(1)
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
(1)
SLS BEAMLINE X06SA
(1)
 
Synchrotron site  (8)
APS
(16)
SLS
(4)
ESRF
(3)
SSRL
(2)
ALS
(1)
Diamond
(1)
NSLS
(1)
PETRA III, EMBL c/o DESY
(1)
 
Diffraction detector type  (2)
CCD
(23)
Pixel
(6)
 
Refinement software  (4)
REFMAC
(14)
PHENIX
(12)
CNS
(2)
CNX
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 BIOQUANTUM (6k x 4k)
(1)
 
NMR
NMR software packages  (1)
CNX
(1)
 
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(1)
600.0 - 700
(1)
700.0 - 800
(1)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 31
Entries 1 to 10 of 31
 Select all entries on this page
Crystal structure of human Survivin bound to histone H3T3phK4ac peptide
Niedzialkowska E, Minor W, Stukenberg PT
Mol Biol Cell (2022) [PMID: 35653296  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Modified residues: ALY    TPO    TPO    ALY   
Assembly name: Survivin homodimer complex and Histone H3.1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127461 (Preferred)   search this ID
PDBe-KB: O15392    P68431   
X-ray diffraction
2.6Å resolution
Released: 12 Jan 2022
Model geometry
Fit model/data
7lbp
7lbp
7lbp
Crystal structure of human Survivin bound to histone H3 T3phK4me3 peptide
Niedzialkowska E, Minor W, Stukenberg PT
Mol Biol Cell (2022) [PMID: 35653296  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Modified residues: M3L    TPO    M3L    TPO   
Assembly name: Survivin homodimer complex and Histone H3.1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127461 (Preferred)   search this ID
PDBe-KB: O15392    P68431   
X-ray diffraction
2.7Å resolution
Released: 12 Jan 2022
Model geometry
Fit model/data
7lbk
7lbk
7lbk
Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
Niedzialkowska E, Minor W, Stukenberg PT
Mol Biol Cell (2022) [PMID: 35653296  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Modified residues: MLZ    TPO    MLZ    TPO   
Assembly name: Survivin homodimer complex and Histone H3.1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127461 (Preferred)   search this ID
PDBe-KB: O15392    P68431   
X-ray diffraction
2.5Å resolution
Released: 12 Jan 2022
Model geometry
Fit model/data
7lbo
7lbo
7lbo
SAD structure of Human Survivin recovered by continuous rotation data collection and multivariate analysis of Friedel pairs
Garcia-Bonete MJ, Katona G
Acta Crystallogr A Found Adv (2019) [PMID: 31692460  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Survivin homodimer complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127460 (Preferred)   search this ID
PDBe-KB: O15392   
X-ray diffraction
3.2000844Å resolution
Released: 6 Nov 2019
Model geometry
Fit model/data
6sho
6sho
6sho
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A.
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    SO4    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-127457 (Preferred)   search this ID
PDBe-KB: O15392    Q53HL2    P68431    Q9NQS7   
X-ray diffraction
2.55Å resolution
Released: 13 May 2020
Model geometry
Fit model/data
6yih
6yih
6yih
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 1.8 A.
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    SO4    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-127457 (Preferred)   search this ID
PDBe-KB: O15392    Q53HL2    P68431    Q9NQS7   
X-ray diffraction
1.81Å resolution
Released: 13 May 2020
Model geometry
Fit model/data
6yif
6yif
6yif
Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
Ruza RR, Barr FA
Biorxiv (2025)
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Modified residues: TPO    TPO   
PDBe complex ID: PDB-CPX-284729 (Preferred)   search this ID
PDBe-KB: O15392    P02281    A0A310TTQ1    P84233    Q53HL2    P62799    (view 2 more)
Electron Microscopy
2.42Å resolution
Released: 5 Feb 2025
Model geometry
Fit model/data
Data not analysed
8rup
8rup
8rup
Structure of a Borealin-INCENP-Survivin complex
Serena M, Elliott PR, Barr FA
J Cell Biol (2020) [PMID: 32356865  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
PDBe complex ID: PDB-CPX-127459 (Preferred)   search this ID
PDBe-KB: O15392    Q53HL2    Q9NQS7   
X-ray diffraction
3.49Å resolution
Released: 13 May 2020
Model geometry
Fit model/data
6yie
6yie
6yie
Crystal structure of a Survivin-Borealin-INCENP core complex
Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E
Cell (2007) [PMID: 17956729  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MES    ZN    ZN   
PDBe complex ID: PDB-CPX-127459 (Preferred)   search this ID
PDBe-KB: O15392    Q53HL2    Q9NQS7   
X-ray diffraction
1.4Å resolution
Released: 6 Nov 2007
Model geometry
Fit model/data
2qfa
2qfa
2qfa
Crystal structure of Borealin (20-78) bound to Survivin (1-120)
Hymowitz SG
J Biol Chem (2007) [PMID: 17881355  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: ZN    ZN   
Assembly name: Borealin and Baculoviral IAP repeat-containing protein 5 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-127458 (Preferred)   search this ID
PDBe-KB: O15392    Q53HL2   
X-ray diffraction
3.3Å resolution
Released: 30 Oct 2007
Model geometry
Fit model/data
2rax
2rax
2rax
Entries 1 to 10 of 31
Entries 1 to 10 of 31