Entry status  (1)

REL

(114)

Experimental methods  (2)

X-ray diffraction

(112)

Solution NMR

(2)

Authors  (380)

Luettgen JM

(41)

Rossi KA

(41)

Wexler RR

(41)

Bozarth JM

(38)

Seiffert DA

(38)

Myers JE

(34)

Sheriff S

(34)

Corte JR

(31)

Quan ML

(31)

Fang T

(28)

Zheng JJ

(26)

Wu Y

(24)

Harper TW

(23)

Jin L

(23)

Lou Z

(21)

Lam PYS

(20)

Strickler JE

(19)

Babine RE

(18)

Ramamurthy V

(17)

Wei A

(17)

Wong PC

(17)

Abdel-Meguid SS

(16)

Bibbins F

(16)

Osuna H

(16)

Ewing WR

(15)

Rendina AR

(14)

Oster L

(13)

Pinto DJP

(13)

Crain EJ

(12)

Olsson T

(12)

Pinto DJ

(12)

Sandmark J

(12)

Wang C

(12)

Morin PE

(11)

Orwat MJ

(11)

Pandey P

(11)

Rynkiewicz M

(11)

Wang Y

(11)

Yang W

(11)

Bruinzeel W

(10)

Cedervall PE

(10)

Chintala M

(10)

DesJarlais RL

(10)

Devine ZH

(10)

Du F

(10)

Gaul MD

(10)

Gilligan PJ

(10)

Li Q

(10)

Liu Z

(10)

Lu T

(10)

Macielag MJ

(10)

Mathur A

(10)

Meyers HV

(10)

Milligan CM

(10)

Myers Jr JE

(10)

Nargund R

(10)

Pietrak B

(10)

Shaffer P

(10)

Shaffer PL

(10)

Silva J

(10)

Smallheer JM

(10)

Smith LM

(10)

Spurlino JC

(10)

Steele RA

(10)

Stratton CF

(10)

Szewczuk LM

(10)

Thieu T

(10)

Wang X

(10)

Wong V

(10)

Xu G

(10)

Zhang J

(10)

Akkaya S

(9)

Beisel H

(9)

Beisel HG

(9)

Eriksson P

(9)

Eriksson PO

(9)

Erixon K

(9)

Fjellstrom O

(9)

Fjellström O

(9)

Gustafsson D

(9)

Jurva U

(9)

Kang D

(9)

Karis D

(9)

Knecht W

(9)

Nerme V

(9)

Nilsson I

(9)

Quinn J

(9)

Redzic A

(9)

Roth R

(9)

Rynkiewicz MJ

(9)

Tigerstrom A

(9)

Tigerström A

(9)

Öster L

(9)

Gorga J

(8)

Gorga JC

(8)

Han W

(8)

Hu Z

(8)

Lai A

(8)

Nagafuji P

(8)

Xin B

(8)

 

More...

Homo / hetero assembly  (2)

homo

(95)

hetero

(19)

Assembly composition  (2)

protein structure

(95)

protein/protein complex

(19)

Assembly polymer count  (4)

monomer

(87)

dimer

(16)

trimer

(8)

tetramer

(3)

Resolution distribution

0.5 - 1

(1)

1.0 - 1.5

(9)

1.5 - 2

(38)

2.0 - 2.5

(41)

2.5 - 3

(21)

3.0 - 3.5

(2)

Release year distribution

2000 - 2005

(7)

2005 - 2010

(23)

2010 - 2015

(25)

2015 - 2020

(64)

2020 - 2025

(32)

Journal  (16)

J Med Chem

(37)

Bioorg Med Chem Lett

(27)

To be published

(12)

PLoS One

(9)

Blood

(4)

J Biol Chem

(4)

ACS Med Chem Lett

(3)

Acta Crystallogr D Biol Crystallogr

(3)

Bioorg Med Chem

(3)

Acta Crystallogr Sect F Struct Biol Cryst Commun

(2)

J Chem Inf Model

(2)

J Thromb Haemost

(2)

Nat Biomed Eng

(2)

Proc Natl Acad Sci U S A

(2)

J Mol Biol

(1)

Structure

(1)

Organism superkingdom  (1)

Eukaryota

(114)

Organism name  (1)

Homo sapiens

(114)

Molecule name  (6)

Coagulation factor XI

(114)

Coagulation factor XIa heavy chain

(114)

Coagulation factor XIa light chain

(114)

FXI

(114)

PTA

(114)

Plasma thromboplastin antecedent

(114)

Molecule type  (1)

Protein

(114)

Gene names  (1)

F11

(114)

Interacting Molecules  (15)

Coagulation factor XIa heavy chain

(7)

Coagulation factor XIa light chain

(7)

Ecotin

(3)

Kininogen-1 light chain

(2)

Double Bridged Peptide F19

(1)

Double Bridged Peptide F21

(1)

FXIA ANTIBODY FAB HEAVY CHAIN

(1)

FXIA ANTIBODY FAB LIGHT CHAIN

(1)

FXIa Antibody FAB Heavy Chain

(1)

FXIa Antibody FAB Light Chain

(1)

LP2

(1)

P39

(1)

Soluble APP-beta

(1)

anti-Factor-XI Fab fragment heavy chain MAA868

(1)

anti-Factor-XI Fab fragment light chain MAA868

(1)

Interacting ligands  (112)

SO4 : SULFATE ION

(72)

EDO : 1,2-ETHANEDIOL

(37)

CIT : CITRIC ACID

(17)

GOL : GLYCEROL

(13)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(9)

BCT : BICARBONATE ION

(5)

BEN : BENZAMIDINE

(5)

DMS : DIMETHYL SULFOXIDE

(3)

TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(3)

7P0 : N-[(1S)-1-benzyl-2-[2-[5-chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide

(2)

CL : CHLORIDE ION

(2)

GSH : GLUTATHIONE

(2)

0TU : 6-chloroquinolin-2(1H)-one

(1)

1T5 : 3'-[(2S,4R)-6-carbamimidoyl-4-methyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]-4-carbamoyl-5'-[(3-methylbutanoyl)amino]biphenyl-2-carboxylic acid

(1)

1T6 : 5-aminocarbonyl-2-[3-[(2S,4R)-6-carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1H-quinolin-2-yl]phenyl]benzoic acid

(1)

339 : (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE

(1)

367 : 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE

(1)

368 : (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE

(1)

39D : 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide

(1)

39F : trans-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-4-(aminomethyl)cyclohexane-1-carboxamide

(1)

3VM : trans-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl}-4-(aminomethyl)cyclohexanecarboxamide

(1)

3Y3 : 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea

(1)

3Y4 : methyl (4-{4-chloro-2-[(1S)-1-({3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}amino)-2-phenylethyl]-1H-imidazol-5-yl}phenyl)carbamate

(1)

3Y5 : 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]urea

(1)

3YU : (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide

(1)

412 : (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE

(1)

421 : 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER

(1)

427 : (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE

(1)

4CE : (2E)-N-[(1S)-1-[5-chloro-4-(4-hydroxy-2-oxo-1,2-dihydroquinolin-6-yl)-1H-imidazol-2-yl]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide

(1)

4D5 : methyl (4-{4-chloro-2-[(1S)-1-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-3-(morpholin-4-yl)-3-oxopropyl]-1H-imidazol-5-yl}phenyl)carbamate

(1)

4GR : methyl (4-{4-chloro-2-[(1S)-1-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2-phenylethyl]-1H-imidazol-5-yl}phenyl)carbamate

(1)

5JM : 4-[(N-{(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}-L-phenylalanyl)amino]benzoic acid

(1)

5SS : 4-(aminomethyl)-~{N}-[(1~{S})-1-[4-(3-oxidanyl-1~{H}-indazol-5-yl)pyridin-2-yl]-2-phenyl-ethyl]cyclohexane-1-carboxamide

(1)

5ST : methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate

(1)

5SU : methyl ~{N}-[4-[2-[(1~{S})-1-[[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate

(1)

624 : 2-(2-(3,4-DICHLOROPHENYL)-5-(ISOPROPYLAMINO)-6-OXOPYRIMIDIN-1(6H)-YL)-N-((S)-1-OXO-1-(THIAZOL-2-YL)-5-GUANIDINOPENTAN-2-YL)ACETAMIDE

(1)

62A : 2-(5-AMINO-6-OXO-2-M-TOLYL-6H-PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-ACETAMIDE

(1)

632 : 2-(5-BENZYLAMINO-2-METHYLSULFANYL-6-OXO-6H-PYRIMIDIN-1-YL)-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-ACETAMIDE

(1)

682 : N~2~-(AMINOCARBONYL)-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[HYDROXY(1,3-THIAZOL-2-YL)METHYL]BUTYL}VALINAMIDE

(1)

709 : N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE

(1)

716 : 2-[2-(3-CHLORO-PHENYL)-2-HYDROXY-ACETYLAMINO]-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-3-METHYL-BUTYRAMIDE

(1)

737 : N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE

(1)

7DK : METHYL ((15S)-15-(((2E)-3-(5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL)-2-PROPENOYL)AMINO)-9-OXO-8,17,19-TRIAZATRICYCLO[14.2.1.0~2,7~]N ONADECA-1(18),2,4,6,16(19)-PENTAEN-5-YL)CARBAMATE

(1)

7DL : ((15S)-18-CHLORO- 15-(((2E)-3-(5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL)-2- PROPENOYL)AMINO)-17,19-DIAZATRICYCLO[14.2.1.0~2,7~]NONADECA-1(18),2,4,6,16(19)-PENTAEN-5-YL)CARBAMATE

(1)

7DS : METHYL ((12E,15S)-15-(((2E)-3-(5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL)-2-PROPENOYL)AMINO)-9-OXO-8,17,19-TRIAZATRICYCLO[14.2.1.0~2, 7~]NONADECA-1(18),2,4,6,12,16(19)-HEXAEN-5-YL)CARBAMATE

(1)

995 : 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE

(1)

9EY : methyl [(7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2-oxo-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecin-14-yl]carbamate

(1)

9F1 : methyl [(4R,5E,8S)-11-chloro-8-[(2,6-difluoro-4-methylbenzene-1-carbonyl)amino]-4-methyl-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate

(1)

9F7 : methyl [(3R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-3-ethyl-2-oxo-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecin-14-yl]carbamate

(1)

9FA : methyl [(4R,5E,8S)-8-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-4-methyl-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate

(1)

9FD : methyl [(4S,8S)-8-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-4-methyl-2-oxo-1,3,4,5,6,7,8,10-octahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate

(1)

9ZM : methyl [(11S)-11-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-6-fluoro-2-oxo-1,3,4,10,11,13-hexahydro-2H-5,9:15,12-di(azeno)-1,13-benzodiazacycloheptadecin-18-yl]carbamate

(1)

ACN : ACETONE

(1)

BUK : N~2~-({[(1R)-1-(4-BROMOPHENYL)ETHYL]AMINO}CARBONYL)ASPARAGINYL-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[2,3-DIHYDRO-1,3-THIAZOL-2-YL(HYDROXY)METHYL]BUTYL}VALINAMIDE

(1)

BUV : 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3-phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid

(1)

BUY : 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid

(1)

BVJ : methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]phenyl]carbamate

(1)

BVM : 4-[[(1~{S})-2-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-5-[(3~{S})-3-ethoxycarbonylpiperidin-1-yl]carbonyl-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]benzoic acid

(1)

E6U : N-[(1S)-1-benzyl-2-(3-guanidinopropylamino)-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide

(1)

EEJ : methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl)carbamate

(1)

FLC : CITRATE ANION

(1)

FUC : alpha-L-fucopyranose

(1)

G0R : N-(4-carbamimidamidobutyl)ethanamide

(1)

HDB : (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE

(1)

IXA : N-[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide

(1)

J1J : N-[(2S)-1-({5-[(diaminomethylidene)amino]pentyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide

(1)

J4X : 6-carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide

(1)

J7B : 2-[2-[[3-[3-(aminomethyl)phenyl]phenyl]carbonylamino]phenyl]ethanoic acid

(1)

MVN : 6-chloro-4-methyl-1H-quinolin-2-one

(1)

NA : SODIUM ION

(1)

NH4 : AMMONIUM ION

(1)

NR7 : methyl [(5E,8S)-8-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate

(1)

NRJ : methyl [(5E,8S)-8-[(6R)-6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate

(1)

NW2 : 2-[2-[3-[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-5-yl]-5-propan-2-yl-phenyl]ethoxy]-3-methoxy-benzoic acid

(1)

NW5 : 2-[2-[[3-[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-5-yl]-5-(2-cyanopropan-2-yl)phenyl]methoxy]phenyl]ethanoic acid

(1)

NWE : 2-[2-[[3-(1,2,3,4-tetrahydroisoquinolin-7-yl)phenyl]methoxy]phenyl]ethanoic acid

(1)

O58 : {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid

(1)

O61 : N-[(2S)-1-({2-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]ethyl}amino)-1-oxo-3-phenylpropan-2-yl]-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-7-carboxamide

(1)

OQ6 : methyl ~{N}-[4-[1-[(1~{R})-1-[5-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]phenyl]carbamate

(1)

OQI : methyl ~{N}-[4-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]phenyl]carbamate

(1)

OQO : 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-6-methyl-pyridin-2-amine

(1)

OR0 : 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-6-fluoranyl-pyridin-2-amine

(1)

ORF : 3-chloranyl-4-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-5-fluoranyl-pyridine

(1)

ORU : 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-1,3-thiazole

(1)

OSX : 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-4-methyl-1,3-thiazole

(1)

OT7 : 5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-2-[(1~{R})-2-cyclopropyl-1-[4-(2-methylpyrazol-3-yl)pyrazol-1-yl]ethyl]-1-oxidanyl-pyridine

(1)

OTJ : Methyl N-[4-[5-chloro-2-[[3-[5-chloro-2-(tetrazol-1-yl)phenyl]propanoylamino]methyl]-1H-imidazol-4-yl]phenyl]carbamate

(1)

OTL : 5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-2-[(1~{R})-2-cyclopropyl-1-[4-(3-methylimidazol-4-yl)pyrazol-1-yl]ethyl]-1-oxidanyl-pyridine

(1)

OTM : (2S)-2-[[(E)-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-phenyl-N-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]propanamide

(1)

OTW : 4-methylquinoline-2,6-diamine

(1)

OTX : 2-[(1~{R})-3-[bis(fluoranyl)methoxy]-1-[4-(3-methyl-1,2,3-triazol-4-yl)pyrazol-1-yl]propyl]-5-[3-chloranyl-6-(4-chloranyl-1,2,3-triazol-1-yl)-2-fluoranyl-phenyl]-1-oxidanyl-pyridine

(1)

PEG : DI(HYDROXYETHYL)ETHER

(1)

PO4 : PHOSPHATE ION

(1)

PRD_001115 : N-[(2S)-1-({2-[5-CHLORO-2-(1H-TETRAZOL-1-YL)PHENYL]ETHYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-7-CARBOXAMIDE

(1)

QEV : methyl [(3R,7S)-7-{[1-(3-chloro-2-fluorophenyl)-5-methyl-1H-imidazole-4-carbonyl]amino}-3-methyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecin-15-yl]carbamate

(1)

QEY : methyl [(3R,7S)-7-{[5-amino-1-(3-chloro-2-fluorophenyl)-1H-pyrazole-4-carbonyl]amino}-3-methyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecin-15-yl]carbamate

(1)

QGS : 1-[(2S)-2-{3-[(3S)-3-amino-2,3-dihydro-1-benzofuran-5-yl]-5-(propan-2-yl)phenyl}-2-hydroxyethyl]-1H-indole-7-carboxylic acid

(1)

QLD : ethyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14-[(methoxycarbonyl)amino]-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecine-2-carboxylate

(1)

QLJ : ethyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-15-[(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecine-2-carboxylate

(1)

QLM : methyl (2R,7S)-7-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14-[(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1H-8,11-epimino-1,9-benzodiazacyclotridecine-2-carboxylate

(1)

 

More...

EC number / name  (1)

3.4.21.27 : Coagulation factor XIa

(114)

Biological function  (7)

serine-type endopeptidase activity

(111)

heparin binding

(4)

hydrolase activity

(4)

peptidase activity

(4)

protein binding

(4)

serine-type aminopeptidase activity

(4)

serine-type peptidase activity

(4)

Biological process  (6)

proteolysis

(114)

blood coagulation

(4)

hemostasis

(4)

plasminogen activation

(4)

positive regulation of fibrinolysis

(4)

regulation of blood coagulation

(4)

Biological cell component  (5)

extracellular region

(7)

extracellular exosome

(4)

extracellular space

(4)

membrane

(4)

plasma membrane

(4)

SCOP fold  (1)

Trypsin-like serine proteases

(4)

Representative Structures

100%

95%

90%

70%

50%

40%

30%