Entry status  (1)

REL

(2)

Experimental methods  (2)

Solution NMR

(1)

X-ray diffraction

(1)

Authors  (15)

Grey LM

(1)

Heath JK

(1)

Hinds MG

(1)

Jones EY

(1)

Maurer T

(1)

Moreau JF

(1)

Nicola NA

(1)

Norton RS

(1)

Robinson RC

(1)

Staunton D

(1)

Stuart DI

(1)

Vankelecom H

(1)

Vernallis AB

(1)

Zhang J-G

(1)

Zhang JG

(1)

Homo / hetero assembly  (1)

homo

(2)

Assembly composition  (1)

protein structure

(2)

Assembly polymer count  (1)

monomer

(2)

Resolution distribution

1.5 - 2

(1)

Release year distribution

1990 - 1995

(1)

1995 - 2000

(2)

Journal  (2)

Cell

(1)

J Biol Chem

(1)

Organism superkingdom  (1)

Eukaryota

(2)

Organism name  (1)

Mus musculus

(2)

Molecule name  (4)

D factor

(2)

Differentiation-stimulating factor

(2)

LIF

(2)

Leukemia inhibitory factor

(2)

Molecule type  (1)

Protein

(2)

Gene names  (1)

Lif

(2)

Biological function  (4)

cytokine activity

(2)

growth factor activity

(2)

leukemia inhibitory factor receptor binding

(2)

signaling receptor binding

(2)

Biological process  (41)

blood vessel remodeling

(2)

cell morphogenesis

(2)

cell population proliferation

(2)

cell surface receptor signaling pathway via STAT

(2)

decidualization

(2)

embryo implantation

(2)

fibroblast proliferation

(2)

gene expression

(2)

immune response

(2)

leukemia inhibitory factor signaling pathway

(2)

lung alveolus development

(2)

lung development

(2)

lung lobe morphogenesis

(2)

lung vasculature development

(2)

maternal process involved in female pregnancy

(2)

meiotic nuclear division

(2)

muscle organ morphogenesis

(2)

negative regulation of ERK1 and ERK2 cascade

(2)

negative regulation of cell population proliferation

(2)

negative regulation of hormone secretion

(2)

negative regulation of meiotic nuclear division

(2)

neuron development

(2)

positive regulation of MAPK cascade

(2)

positive regulation of astrocyte differentiation

(2)

positive regulation of cell adhesion mediated by integrin

(2)

positive regulation of cell population proliferation

(2)

positive regulation of fibroblast proliferation

(2)

positive regulation of gene expression

(2)

positive regulation of macrophage differentiation

(2)

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

(2)

positive regulation of receptor signaling pathway via STAT

(2)

positive regulation of transcription by RNA polymerase II

(2)

regulation of cell communication

(2)

regulation of cell differentiation

(2)

regulation of metanephric nephron tubule epithelial cell differentiation

(2)

regulation of signaling

(2)

response to hypoxia

(2)

somatic stem cell population maintenance

(2)

spongiotrophoblast differentiation

(2)

stem cell differentiation

(2)

trophoblast giant cell differentiation

(2)

Biological cell component  (3)

cytosol

(2)

extracellular region

(2)

extracellular space

(2)

SCOP fold  (1)

4-helical cytokines

(2)

SCOP family  (1)

Long-chain cytokines

(2)

CATH class  (1)

Mainly Alpha

(2)

CATH topology  (1)

Growth Hormone; Chain: A;

(2)

Pfam accession / name  (1)

PF01291 : LIF_OSM

(2)

Refinement software  (2)

X-PLOR

(2)

DYANA

(1)

NMR software packages  (2)

DYANA

(1)

X-PLOR

(1)

NMR Field Strength

500.0 - 600

(1)

600.0 - 700

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%