Entry status  (1)

REL

(8)

Experimental methods  (2)

X-ray diffraction

(5)

Electron Microscopy

(3)

Authors  (31)

Andersen GR

(4)

Croll TI

(3)

De la O Becerra KI

(3)

Gros P

(3)

Lorent JH

(3)

Oosterheert W

(3)

Rooijakkers SHM

(3)

Ruyken M

(3)

Schouten A

(3)

Xenaki KT

(3)

van Bergen En Henegouwen PMP

(3)

van den Bos RM

(3)

Carroll MC

(1)

Clemenza L

(1)

Fox R

(1)

Hansen A

(1)

Isenman DE

(1)

Johnson MB

(1)

Laursen NS

(1)

Martin A

(1)

Olesen HG

(1)

Presumey J

(1)

Rose DR

(1)

Simoni L

(1)

Stevens B

(1)

Thiel S

(1)

Wong V

(1)

Yalcin E

(1)

Zarantonello A

(1)

van den Elsen JM

(1)

van den Elsen JMH

(1)

Homo / hetero assembly  (2)

hetero

(7)

homo

(1)

Assembly composition  (2)

protein/protein complex

(7)

protein structure

(1)

Assembly polymer count  (4)

tetramer

(4)

trimer

(2)

monomer

(1)

pentamer

(1)

Resolution distribution

2.0 - 2.5

(1)

3.0 - 3.5

(4)

3.5 - 4

(3)

Release year distribution

2000 - 2005

(1)

2015 - 2020

(4)

2020 - 2025

(4)

Journal  (3)

J Immunol

(4)

Acta Crystallogr D Struct Biol

(3)

J Mol Biol

(1)

Organism superkingdom  (1)

Eukaryota

(8)

Organism name  (1)

Homo sapiens

(8)

Molecule name  (21)

Acidic complement C4

(8)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2

(8)

C4a anaphylatoxin

(8)

C4b-A

(8)

C4d-A

(8)

Complement C4 beta chain

(8)

Complement C4 gamma chain

(8)

Complement C4-A

(8)

Complement C4-A alpha chain

(8)

Basic complement C4

(1)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3

(1)

C4b-B

(1)

C4d-B

(1)

Complement C4-B

(1)

Complement C4-B alpha chain

(1)

MASP-2

(1)

MBL-associated serine protease 2

(1)

Mannan-binding lectin serine protease 2

(1)

Mannan-binding lectin serine protease 2 A chain

(1)

Mannan-binding lectin serine protease 2 B chain

(1)

Mannose-binding protein-associated serine protease 2

(1)

Molecule type  (1)

Protein

(8)

Gene names  (7)

C4A

(8)

CO4

(8)

CPAMD2

(8)

C4B

(1)

C4B_2

(1)

CPAMD3

(1)

MASP2

(1)

Interacting Molecules  (10)

Complement C4 beta chain

(7)

Complement C4 gamma chain

(7)

Complement C4-A alpha chain

(5)

C4b-A

(2)

Anti-C4b nanobody B12

(1)

Anti-C4b nanobody E3

(1)

Mannan-binding lectin serine protease 2 A chain

(1)

Mannan-binding lectin serine protease 2 B chain

(1)

Nanobody B5

(1)

hC4Nb8 nanobody

(1)

Interacting ligands  (5)

NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose

(7)

BMA : beta-D-mannopyranose

(3)

A2G : 2-acetamido-2-deoxy-alpha-D-galactopyranose

(1)

MAN : alpha-D-mannopyranose

(1)

PBM : TRIMETHYL LEAD ION

(1)

EC number / name  (2)

3.4.21.104 : Mannan-binding lectin-associated serine protease-2

(1)

3.4.21.43 : Classical-complement-pathway C3/C5 convertase

(1)

Biological function  (2)

endopeptidase inhibitor activity

(7)

serine-type endopeptidase activity

(1)

Biological process  (3)

complement activation

(5)

inflammatory response

(5)

proteolysis

(1)

Biological cell component  (2)

extracellular space

(8)

extracellular region

(7)

SCOP fold  (1)

alpha/alpha toroid

(1)

SCOP family  (1)

Complement components

(1)

CATH class  (3)

Mainly Alpha

(4)

Mainly Beta

(3)

Special

(3)

CATH topology  (9)

Glycosyltransferase

(4)

Immunoglobulin-like

(3)

Jelly Rolls

(3)

N-terminal domain of TfIIb

(3)

S-adenosyl-L-methionine-dependent methyltransferases

(3)

Influenza Virus Matrix Protein; Chain A, domain 1

(2)

OB fold (Dihydrolipoamide Acetyltransferase, E2P)

(2)

Complement Module; domain 1

(1)

Thrombin, subunit H

(1)

Pfam accession / name  (13)

PF07678 : TED_complement

(8)

PF00207 : A2M

(7)

PF01759 : NTR

(7)

PF01835 : MG2

(7)

PF07677 : A2M_recep

(7)

PF07703 : A2M_BRD

(7)

PF17789 : MG4

(7)

PF17791 : MG3

(7)

PF21145 : C4_MG1

(7)

PF22661 : CO4A-B_CUB_C

(7)

PF01821 : ANATO

(5)

PF00084 : Sushi

(1)

PF00089 : Trypsin

(1)

Diffraction protocol  (1)

Single wavelength

(5)

Diffraction radiation source type  (2)

Synchrotron

(4)

Rotating anode

(1)

Diffraction source  (5)

ESRF BEAMLINE ID29

(2)

SOLEIL BEAMLINE PROXIMA 1

(2)

ESRF BEAMLINE ID23-1

(1)

PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)

(1)

RIGAKU RU200

(1)

Synchrotron site  (3)

ESRF

(3)

SOLEIL

(2)

PETRA III, EMBL c/o DESY

(1)

Diffraction detector type  (3)

Pixel

(4)

CCD

(2)

Image plate

(1)

Refinement software  (2)

PHENIX

(7)

CNS

(1)

EM microscope model  (1)

FEI TALOS ARCTICA

(3)

EM detector name  (1)

GATAN K2 SUMMIT (4k x 4k)

(3)

Representative Structures

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