Entry status  (1)

REL

(8)

Experimental methods  (2)

Solution NMR

(5)

X-ray diffraction

(3)

Authors  (35)

Guo Q

(3)

LiWang PJ

(3)

Ren M

(3)

Tang WJ

(3)

Clore GM

(2)

Derider M

(2)

Garrett DS

(2)

Gronenborn AM

(2)

Isern N

(2)

Jao SC

(2)

Kuszewski J

(2)

Leonard WJ

(2)

Liang WG

(2)

Liwang PJ

(2)

Lodi PJ

(2)

McCornack MA

(2)

Moyer R

(2)

Ness T

(2)

Tsang ML

(2)

Weatherbee JA

(2)

Zhang L

(2)

Zhao F

(2)

Dinner AR

(1)

Guo L

(1)

Jao S

(1)

Kim S

(1)

Koenen RR

(1)

Laurence JS

(1)

Lenz M

(1)

Qian F

(1)

Schilling AB

(1)

Tang W

(1)

Weber C

(1)

Xu H

(1)

Ye RD

(1)

Homo / hetero assembly  (2)

homo

(5)

hetero

(3)

Assembly composition  (2)

protein structure

(5)

protein/protein complex

(3)

Assembly polymer count  (2)

dimer

(6)

monomer

(2)

Resolution distribution

1.5 - 2

(1)

2.5 - 3

(1)

3.0 - 3.5

(1)

Release year distribution

1990 - 1995

(2)

2000 - 2005

(1)

2005 - 2010

(3)

2010 - 2015

(3)

2015 - 2020

(1)

Journal  (5)

J Mol Biol

(2)

Proc Natl Acad Sci U S A

(2)

Science

(2)

Biochemistry

(1)

EMBO J

(1)

Organism superkingdom  (2)

Eukaryota

(8)

Viruses

(2)

Organism name  (2)

Homo sapiens

(8)

Rabbitpox virus

(2)

Molecule name  (21)

ACT-2

(8)

C-C motif chemokine 4

(8)

G-26 T-lymphocyte-secreted protein

(8)

HC21

(8)

LAG-1

(8)

Lymphocyte activation gene 1 protein

(8)

MIP-1-beta

(8)

MIP-1-beta(1-69)

(8)

MIP-1-beta(3-69)

(8)

Macrophage inflammatory protein 1-beta

(8)

PAT 744

(8)

Protein H400

(8)

SIS-gamma

(8)

Small-inducible cytokine A4

(8)

T-cell activation protein 2

(8)

35kDa major secreted protein

(2)

Abeta-degrading protease

(1)

Insulin protease

(1)

Insulin-degrading enzyme

(1)

Insulinase

(1)

Insulysin

(1)

Molecule type  (1)

Protein

(8)

Gene names  (5)

CCL4

(8)

LAG1

(8)

MIP1B

(8)

SCYA4

(8)

IDE

(1)

Interacting Molecules  (3)

C-C motif chemokine 4

(3)

35kDa major secreted protein

(2)

Insulin-degrading enzyme

(1)

Interacting ligands  (2)

ZN : ZINC ION

(2)

GOL : GLYCEROL

(1)

EC number / name  (1)

3.4.24.56 : Insulysin

(1)

Biological function  (26)

CCR chemokine receptor binding

(8)

CCR1 chemokine receptor binding

(8)

CCR5 chemokine receptor binding

(8)

chemokine activity

(8)

cytokine activity

(8)

identical protein binding

(8)

protein binding

(8)

ATP binding

(1)

ATP hydrolysis activity

(1)

amyloid-beta binding

(1)

beta-endorphin binding

(1)

catalytic activity

(1)

endopeptidase activity

(1)

hydrolase activity

(1)

insulin binding

(1)

metal ion binding

(1)

metalloendopeptidase activity

(1)

metallopeptidase activity

(1)

nucleotide binding

(1)

peptidase activity

(1)

peptide binding

(1)

peptide hormone binding

(1)

protein homodimerization activity

(1)

protein-containing complex binding

(1)

virus receptor activity

(1)

zinc ion binding

(1)

Biological process  (36)

antimicrobial humoral immune response mediated by antimicrobial peptide

(8)

cell adhesion

(8)

cell-cell signaling

(8)

chemokine-mediated signaling pathway

(8)

chemotaxis

(8)

eosinophil chemotaxis

(8)

establishment or maintenance of cell polarity

(8)

immune response

(8)

inflammatory response

(8)

negative regulation by host of viral transcription

(8)

positive regulation of calcium ion transport

(8)

positive regulation of calcium-mediated signaling

(8)

positive regulation of cell migration

(8)

positive regulation of natural killer cell chemotaxis

(8)

response to toxic substance

(8)

response to virus

(8)

signal transduction

(8)

amyloid-beta clearance

(1)

amyloid-beta clearance by cellular catabolic process

(1)

amyloid-beta metabolic process

(1)

antigen processing and presentation of endogenous peptide antigen via MHC class I

(1)

bradykinin catabolic process

(1)

hormone catabolic process

(1)

insulin catabolic process

(1)

insulin metabolic process

(1)

insulin receptor signaling pathway

(1)

negative regulation of proteolysis

(1)

peptide catabolic process

(1)

positive regulation of protein binding

(1)

positive regulation of protein catabolic process

(1)

protein catabolic process

(1)

proteolysis

(1)

proteolysis involved in protein catabolic process

(1)

regulation of aerobic respiration

(1)

symbiont entry into host cell

(1)

ubiquitin recycling

(1)

Biological cell component  (15)

extracellular region

(8)

extracellular space

(8)

basolateral plasma membrane

(1)

cell surface

(1)

cytoplasm

(1)

cytosol

(1)

cytosolic proteasome complex

(1)

external side of plasma membrane

(1)

extracellular exosome

(1)

membrane

(1)

mitochondrion

(1)

nucleus

(1)

peroxisomal matrix

(1)

peroxisome

(1)

plasma membrane

(1)

SCOP fold  (1)

IL8-like

(3)

SCOP family  (1)

Interleukin 8-like chemokines

(3)

CATH class  (2)

Mainly Beta

(7)

Alpha Beta

(1)

CATH topology  (3)

OB fold (Dihydrolipoamide Acetyltransferase, E2P)

(7)

Viral Chemokine Inhibitor; Chain A

(2)

Cytochrome Bc1 Complex; Chain A, domain 1

(1)

Pfam accession / name  (5)

PF00048 : IL8

(8)

PF02250 : Orthopox_35kD

(2)

PF00675 : Peptidase_M16

(1)

PF05193 : Peptidase_M16_C

(1)

PF16187 : Peptidase_M16_M

(1)

Diffraction protocol  (1)

Single wavelength

(6)

Diffraction radiation source type  (1)

Synchrotron

(3)

Diffraction source  (1)

APS BEAMLINE 19-ID

(3)

Synchrotron site  (1)

APS

(3)

Diffraction detector type  (1)

CCD

(3)

Refinement software  (2)

PHENIX

(2)

REFMAC

(1)

NMR software packages  (3)

DYNAMO

(2)

NMRPipe

(2)

CNS

(1)

NMR Field Strength

400.0 - 500

(1)

500.0 - 600

(3)

600.0 - 700

(3)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

100%

95%

90%

70%

50%

40%

30%