Uniprot accession / id : P15248  OR   Uniprot accession / id : P15247
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Entry Information
Entry status  (1)
REL
(7)
 
Experimental methods  (2)
X-ray diffraction
(6)
Solution NMR
(1)
 
Authors  (15)
Bick F
(6)
Blanchetot C
(6)
De Vos T
(6)
Dumoutier L
(6)
Evangelidis T
(6)
Godar M
(6)
Markovic I
(6)
Mortier E
(6)
Papageorgiou AC
(6)
Savvides SN
(6)
Tripsianes K
(6)
Kim JW
(1)
Lee J-O
(1)
Papageorgiou A
(1)
Park SM
(1)
 
Homo / hetero assembly  (2)
hetero
(5)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(5)
protein structure
(2)
 
Assembly polymer count  (3)
trimer
(4)
monomer
(2)
dimer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(1)
3.0 - 3.5
(3)
 
Release year distribution
2020 - 2025
(7)
 
Journal  (2)
Biorxiv
(6)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(7)
 
Organism name  (2)
Homo sapiens
(5)
Mus musculus
(2)
 
Molecule name  (4)
Cytokine P40
(7)
IL-9
(7)
Interleukin-9
(7)
T-cell growth factor P40
(7)
 
Molecule type  (1)
Protein
(7)
 
Gene names  (2)
IL9
(5)
Il9
(2)
 
Interacting Molecules  (9)
Heavy chain (Fab 35D8)
(1)
Heavy chain (Fab 6D3)
(1)
Heavy chain (Fab 6E2)
(1)
Heavy chain (Fab 7D6)
(1)
Interleukin-9 receptor
(1)
Light chain (Fab 35D8)
(1)
Light chain (Fab 6D3)
(1)
Light chain (Fab 6E2)
(1)
Light chain (Fab 7D6)
(1)
 
Interacting ligands  (4)
SO4 : SULFATE ION
(2)
ACT : ACETATE ION
(1)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(1)
ZN : ZINC ION
(1)
 
Function and Biology
Biological function  (4)
cytokine activity
(7)
cytokine receptor binding
(7)
growth factor activity
(7)
interleukin-9 receptor binding
(5)
 
Biological process  (10)
B cell differentiation
(7)
B cell proliferation
(7)
immune response
(7)
immunoglobulin mediated immune response
(7)
interleukin-9-mediated signaling pathway
(7)
positive regulation of interleukin-5 production
(7)
regulation of receptor signaling pathway via JAK-STAT
(7)
inflammatory response
(5)
positive regulation of cell growth
(5)
positive regulation of cell population proliferation
(5)
 
Biological cell component  (2)
extracellular region
(7)
extracellular space
(7)
 
Representative Structures
Representative Structures
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Entries 1 to 7 of 7
Entries 1 to 7 of 7
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7xcb
Crystal structure of the mouse interleukin-9
Kim JW, Lee J-O, Park SM
To be published
Source organism: Mus musculus  
Assembly composition: protein only structure
Bound ligands: NAG    NAG   
Assembly name: Interleukin-9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147276 (Preferred)   search this ID
PDBe-KB: P15247   
X-ray diffraction
3.4Å resolution
Released: 29 Mar 2023
DOI: 10.2210/pdb7xcb  
Model geometry
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7xcb
7xcb
7xcb
7ox2
Fab 6E2: hIL-9 complex
De Vos T, Savvides SN
Biorxiv (2022)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Interleukin-9 and IG-heavy chain and IG-light lambda chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-279809 (Preferred)   search this ID
PDBe-KB: P15248   
X-ray diffraction
3.34Å resolution
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox2  
Model geometry
Fit model/data
7ox2
7ox2
7ox2
7ox1
Fab 7D6: hIL-9 complex
De Vos T, Savvides SN
Biorxiv (2022)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Interleukin-9 and IG-heavy chain and IG-light lambda chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-210629 (Preferred)   search this ID
PDBe-KB: P15248   
X-ray diffraction
2.49Å resolution
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox1  
Model geometry
Fit model/data
7ox1
7ox1
7ox1
7ox4
Mouse interleukin-9 in complex with Fab 35D8.
De Vos T, Savvides SN
Biorxiv (2022)
Source organism: Mus musculus  
Assembly composition: protein/protein complex
Bound ligands: ACT    ZN    ZN    ACT   
Assembly name: Interleukin-9 and IG-heavy chain and IG-light lambda chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-210628 (Preferred)   search this ID
PDBe-KB: P15247   
X-ray diffraction
1.8Å resolution
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox4  
Model geometry
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7ox4
7ox4
7ox4
7ox5
hIL-9:hIL-9Ra complex
De Vos T, Savvides SN
Biorxiv (2022)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Interleukin-9 and Interleukin-9 receptor (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147279 (Preferred)   search this ID
PDBe-KB: P15248    Q01113   
X-ray diffraction
3.09Å resolution
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox5  
Model geometry
Fit model/data
7ox5
7ox5
7ox5
7ox3
Fab 6D3: hIL-9 complex
De Vos T, Savvides SN
Biorxiv (2022)
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Interleukin-9 and IG-light lambda chain and IG-heavy chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-210631 (Preferred)   search this ID
PDBe-KB: P15248   
X-ray diffraction
1.7Å resolution
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox3  
Model geometry
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7ox3
7ox3
7ox3
7ox6
Solution structure of human interleukin-9
Savvides SN, Tripsianes K, De Vos T, Papageorgiou A, Evangelidis T
Biorxiv (2022)
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Interleukin-9 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147278 (Preferred)   search this ID
PDBe-KB: P15248   
Solution NMR
Released: 28 Dec 2022
DOI: 10.2210/pdb7ox6  
Model geometry
Fit model/data
Data not analysed
7ox6
7ox6
7ox6
Entries 1 to 7 of 7
Entries 1 to 7 of 7