Uniprot accession / id : P22914  OR   Uniprot accession / id : P06504  OR   Uniprot accession / id : O35486  OR   Uniprot accession / id : Q3UPY3  OR   Uniprot accession / id : Q5XTP1  OR   Uniprot accession / id : Q5XTP0
 
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Entry Information
Entry status  (1)
REL
(18)
 
Experimental methods  (2)
X-ray diffraction
(12)
Solution NMR
(6)
 
Authors  (49)
Martin RW
(9)
Kwok AO
(7)
Mehrabi P
(7)
Miller RJD
(7)
Norton-Baker B
(7)
von Stetten D
(7)
Rocha MA
(6)
Roskamp KW
(6)
Sprague-Piercy MA
(6)
Bax A
(3)
Wistow G
(3)
Brindley AJ
(2)
Brubaker WD
(2)
Delaglio F
(2)
Diehl A
(2)
Kingsley CN
(2)
Lubsen NH
(2)
Markovic S
(2)
Oschkinat H
(2)
Sagar V
(2)
Slingsby C
(2)
Wu Z
(2)
Wyatt K
(2)
Bari KJ
(1)
Basak AK
(1)
Bateman OA
(1)
Boger J
(1)
Carver JA
(1)
Chary KVR
(1)
Goodfellow JM
(1)
Grishaev A
(1)
Grosas AB
(1)
Jackson CJ
(1)
Jaenicke R
(1)
Kroone RC
(1)
Mabbitt PD
(1)
Naylor CE
(1)
Purkiss AG
(1)
Ray NJ
(1)
Redecke L
(1)
Schikora H
(1)
Schonherr R
(1)
Schulz EC
(1)
Schönherr R
(1)
Sharma S
(1)
Thorn DC
(1)
Trewhella J
(1)
Wistow GJ
(1)
Wu J
(1)
 
Homo / hetero assembly  (1)
homo
(18)
 
Assembly composition  (1)
protein structure
(18)
 
Assembly polymer count  (3)
monomer
(13)
dimer
(3)
octamer
(2)
 
Resolution distribution
1.0 - 1.5
(3)
1.5 - 2
(2)
2.0 - 2.5
(3)
2.5 - 3
(4)
 
Release year distribution
1995 - 2000
(1)
2000 - 2005
(4)
2005 - 2010
(3)
2010 - 2015
(2)
2015 - 2020
(3)
2020 - 2025
(8)
 
Journal  (9)
Structure
(8)
J Mol Biol
(2)
Protein Sci
(2)
Acta Crystallogr D Struct Biol
(1)
J Am Chem Soc
(1)
J Biol Chem
(1)
J Struct Biol
(1)
Protein Eng
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(18)
 
Organism name  (3)
Homo sapiens
(12)
Mus musculus
(5)
Bos taurus
(1)
 
Molecule name  (3)
Beta-crystallin S
(18)
Gamma-S-crystallin
(18)
Gamma-crystallin S
(18)
 
Molecule type  (1)
Protein
(18)
 
Gene names  (3)
CRYGS
(13)
CRYG8
(12)
Crygs
(5)
 
Interacting ligands  (2)
BTB : 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(2)
SO4 : SULFATE ION
(1)
 
Function and Biology
Biological function  (2)
structural constituent of eye lens
(16)
protein binding
(11)
 
Biological process  (4)
lens development in camera-type eye
(16)
morphogenesis of an epithelium
(16)
visual perception
(11)
eye development
(5)
 
Sequence and Structure classification
SCOP fold  (1)
gamma-Crystallin-like
(2)
 
SCOP family  (1)
Crystallins/Ca-binding development proteins
(2)
 
CATH class  (1)
Mainly Beta
(8)
 
CATH topology  (1)
Gamma-B Crystallin; domain 1
(8)
 
Pfam accession / name  (1)
PF00030 : Crystall
(18)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(14)
 
Diffraction radiation source type  (1)
Synchrotron
(12)
 
Diffraction source  (6)
PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
(6)
APS BEAMLINE 24-ID-E
(2)
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
(1)
PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
(1)
SRS BEAMLINE PX7.2
(1)
SRS BEAMLINE PX9.6
(1)
 
Synchrotron site  (4)
PETRA III, EMBL c/o DESY
(7)
APS
(2)
SRS
(2)
Australian Synchrotron
(1)
 
Diffraction detector type  (3)
Pixel
(9)
CCD
(1)
Image plate
(1)
 
Refinement software  (3)
PHENIX
(10)
CNS
(1)
X-PLOR
(1)
 
NMR
NMR software packages  (10)
NMRPipe
(5)
Sparky
(3)
Xplor-NIH
(3)
CcpNmr Analysis
(2)
DYNAMO
(2)
VNMR
(2)
CARA
(1)
CNS
(1)
CYANA
(1)
X-PLOR
(1)
 
NMR Field Strength
500.0 - 600
(3)
600.0 - 700
(4)
700.0 - 800
(3)
800.0 - 900
(2)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 18
Entries 1 to 10 of 18
 Select all entries on this page
Solution-state NMR structure of G57W human gammaS crystallin
Sharma S, Bari KJ, Chary KVR
J Struct Biol (2019) [PMID: 30769148  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
Solution NMR
Released: 10 Apr 2019
Model geometry
Fit model/data
Data not analysed
6if9
6if9
6if9
Crystal structure of wild-type human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
2Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n36
7n36
7n36
Crystal structure of 7-site deamidated variant of human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
1.56Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n39
7n39
7n39
Mouse Gamma S Crystallin L16 Octamer
Sagar V, Wistow GJ
To be published
Source organism: Mus musculus  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-128694 (Preferred)   search this ID
PDBe-KB: O35486   
X-ray diffraction
2.919Å resolution
Released: 14 Nov 2018
Model geometry
Fit model/data
6myg
6myg
6myg
Crystal structure of 3-site deamidated variant of human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: BTB    MG    BTB    MG   
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
1.3Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n37
7n37
7n37
Crystal structure of 9-site deamidated variant of human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
1.5Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n3a
7n3a
7n3a
Crystal structure of aged 9-site deamidated variant of human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
2.09Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n3b
7n3b
7n3b
gamma(S)-crystallin 9-site deamidation mutant grown inside HARE serial crystallography chip
Norton-Baker B, Mehrabi P, Boger J, Schonherr R, von Stetten D, Schikora H, Martin RW, Miller RJD, Redecke L, Schulz EC
Acta Crystallogr D Struct Biol (2021) [PMID: 34076595  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149841 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
3Å resolution
Released: 16 Jun 2021
Model geometry
Fit model/data
7nje
7nje
7nje
Crystal structure of 5-site deamidated variant of human gamma(S)-crystallin
Norton-Baker B, Mehrabi P, Martin RW
Structure (2022) [PMID: 35338852  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: BTB    MG    BTB    MG   
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149840 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
1.22Å resolution
Released: 23 Mar 2022
Model geometry
Fit model/data
7n38
7n38
7n38
Gamma-s crystallin dimer
Mabbitt PD, Thorn DC, Jackson CJ, Carver JA
J Mol Biol (2019) [PMID: 30552875  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Gamma-crystallin S (Preferred)   search this complex
PDBe complex ID: PDB-CPX-149841 (Preferred)   search this ID
PDBe-KB: P22914   
X-ray diffraction
2.1Å resolution
Released: 26 Dec 2018
Model geometry
Fit model/data
6fd8
6fd8
6fd8
Entries 1 to 10 of 18
Entries 1 to 10 of 18