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(1)
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(29)
Lowman H
(2)
Quan C
(2)
Reilly D
(2)
Skelton NJ
(2)
Akashi S
(1)
Casagrande F
(1)
Chu M
(1)
Das BB
(1)
De Angelis A
(1)
De Angelis AA
(1)
Inoue A
(1)
Ishimoto N
(1)
Kawakami K
(1)
Kiefer H
(1)
Maier K
(1)
Marassi FM
(1)
Mizutani K
(1)
Nothnagel H
(1)
Nothnagel HJ
(1)
Opella SJ
(1)
Park JH
(1)
Park S
(1)
Park SH
(1)
Park SY
(1)
Rajarathnam K
(1)
Sepuru KM
(1)
Tajiri M
(1)
Tame JRH
(1)
Tian Y
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Homo / hetero assembly
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homo
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protein structure
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trimer
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hexamer
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monomer
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3.0 - 3.5
(1)
Release year distribution
1995 - 2000
(2)
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Structure
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Eukaryota
(5)
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Homo sapiens
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(7)
C-X-C chemokine receptor type 1
(5)
CDw128a
(5)
CXC-R1
(5)
CXCR-1
(5)
High affinity interleukin-8 receptor A
(5)
IL-8 receptor type 1
(5)
IL-8R A
(5)
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(1)
Protein
(5)
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(3)
CMKAR1
(5)
CXCR1
(5)
IL8RA
(5)
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(6)
Interleukin-8
(3)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-1
(1)
IL-8(9-77)
(1)
scFv16
(1)
Function and Biology
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(8)
C-X-C chemokine receptor activity
(2)
G protein-coupled receptor activity
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interleukin-8 binding
(2)
C-C chemokine binding
(1)
C-C chemokine receptor activity
(1)
chemokine receptor activity
(1)
interleukin-8 receptor activity
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protein binding
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Biological process
(12)
G protein-coupled receptor signaling pathway
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chemotaxis
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calcium-mediated signaling
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cell surface receptor signaling pathway
(1)
chemokine-mediated signaling pathway
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dendritic cell chemotaxis
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immune response
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interleukin-8-mediated signaling pathway
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neutrophil chemotaxis
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positive regulation of cytosolic calcium ion concentration
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receptor internalization
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signal transduction
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membrane
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plasma membrane
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Rhopdopsin 7-helix transmembrane proteins
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Pfam accession / name
(1)
PF00001 : 7tm_1
(2)
Experimental Information
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400.0 - 500
(2)
500.0 - 600
(2)
700.0 - 800
(2)
800.0 - 900
(1)
Representative Structures
Representative Structures
Entries
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Entries 1 to 5 of 5
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Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer
Ishimoto N, Park JH, Park SY
Nat Commun
(2023)
[PMID: 37433790 ]
Source organisms: Mus musculus , Homo sapiens
Assembly composition: protein/protein complex
PDBe complex ID:
PDB-CPX-273130 (Preferred)
search this ID
Solution NMR CXCL8-CXCR1 N-domain complex structure
Sepuru KM, Rajarathnam K
To be published
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
C-X-C chemokine receptor type 1 and Interleukin-8
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-145179 (Preferred)
search this ID
CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8
Skelton NJ, Quan C, Lowman H
Structure
(1999)
[PMID: 10368283 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
CXCL8-CXCR1 receptor-ligand complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-145182 (Preferred)
search this ID
Structure of human CXCR1 in phospholipid bilayers
Park S, Das BB, Casagrande F, Nothnagel H, Chu M, Kiefer H, Maier K, De Angelis A, Marassi FM, Opella SJ
Nature
(2012)
[PMID: 23086146 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
C-X-C chemokine receptor type 1
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-150329 (Preferred)
search this ID

CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8 (MINIMIZED MEAN)
Skelton NJ, Quan C, Lowman H
Structure
(1999)
[PMID: 10368283 ]
Source organism: Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
CXCL8-CXCR1 receptor-ligand complex
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-145182 (Preferred)
search this ID
Entries 1 to 5 of 5