Uniprot accession / id : P25024  OR   Uniprot accession / id : P55920  OR   Uniprot accession / id : Q810W6  OR   Uniprot accession / id : P70612
 
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Entry Information
Entry status  (1)
REL
(5)
 
Experimental methods  (3)
Solution NMR
(3)
Electron Microscopy
(1)
Solid-state NMR
(1)
 
Authors  (29)
Lowman H
(2)
Quan C
(2)
Reilly D
(2)
Skelton NJ
(2)
Akashi S
(1)
Casagrande F
(1)
Chu M
(1)
Das BB
(1)
De Angelis A
(1)
De Angelis AA
(1)
Inoue A
(1)
Ishimoto N
(1)
Kawakami K
(1)
Kiefer H
(1)
Maier K
(1)
Marassi FM
(1)
Mizutani K
(1)
Nothnagel H
(1)
Nothnagel HJ
(1)
Opella SJ
(1)
Park JH
(1)
Park S
(1)
Park SH
(1)
Park SY
(1)
Rajarathnam K
(1)
Sepuru KM
(1)
Tajiri M
(1)
Tame JRH
(1)
Tian Y
(1)
 
Homo / hetero assembly  (2)
hetero
(4)
homo
(1)
 
Assembly composition  (2)
protein/protein complex
(4)
protein structure
(1)
 
Assembly polymer count  (4)
trimer
(2)
dimer
(1)
hexamer
(1)
monomer
(1)
 
Resolution distribution
3.0 - 3.5
(1)
 
Release year distribution
1995 - 2000
(2)
2010 - 2015
(1)
2020 - 2025
(2)
 
Journal  (4)
Structure
(2)
Nat Commun
(1)
Nature
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(5)
 
Organism name  (1)
Homo sapiens
(5)
 
Molecule name  (7)
C-X-C chemokine receptor type 1
(5)
CDw128a
(5)
CXC-R1
(5)
CXCR-1
(5)
High affinity interleukin-8 receptor A
(5)
IL-8 receptor type 1
(5)
IL-8R A
(5)
 
Molecule type  (1)
Protein
(5)
 
Gene names  (3)
CMKAR1
(5)
CXCR1
(5)
IL8RA
(5)
 
Interacting Molecules  (6)
Interleukin-8
(3)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(1)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
(1)
Guanine nucleotide-binding protein G(i) subunit alpha-1
(1)
IL-8(9-77)
(1)
scFv16
(1)
 
Function and Biology
Biological function  (8)
C-X-C chemokine receptor activity
(2)
G protein-coupled receptor activity
(2)
interleukin-8 binding
(2)
C-C chemokine binding
(1)
C-C chemokine receptor activity
(1)
chemokine receptor activity
(1)
interleukin-8 receptor activity
(1)
protein binding
(1)
 
Biological process  (12)
G protein-coupled receptor signaling pathway
(2)
chemotaxis
(2)
calcium-mediated signaling
(1)
cell surface receptor signaling pathway
(1)
chemokine-mediated signaling pathway
(1)
dendritic cell chemotaxis
(1)
immune response
(1)
interleukin-8-mediated signaling pathway
(1)
neutrophil chemotaxis
(1)
positive regulation of cytosolic calcium ion concentration
(1)
receptor internalization
(1)
signal transduction
(1)
 
Biological cell component  (4)
membrane
(2)
external side of plasma membrane
(1)
plasma membrane
(1)
secretory granule membrane
(1)
 
Sequence and Structure classification
CATH class  (1)
Mainly Alpha
(1)
 
CATH topology  (1)
Rhopdopsin 7-helix transmembrane proteins
(1)
 
Pfam accession / name  (1)
PF00001 : 7tm_1
(2)
 
Experimental Information
Refinement software  (2)
AMBER
(1)
PHENIX
(1)
 
EM microscope model  (1)
FEI TITAN KRIOS
(1)
 
EM detector name  (1)
GATAN K3 (6k x 4k)
(1)
 
NMR
NMR software packages  (7)
Discover
(2)
ARIA
(1)
MSI DISCOVER
(1)
MSI DISCOVER DISCOVER
(1)
Sparky
(1)
TopSpin
(1)
Xplor-NIH
(1)
 
NMR Field Strength
400.0 - 500
(2)
500.0 - 600
(2)
700.0 - 800
(2)
800.0 - 900
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 5 of 5
Entries 1 to 5 of 5
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Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer
Ishimoto N, Park JH, Park SY
Nat Commun (2023) [PMID: 37433790  ]
Assembly composition: protein/protein complex
PDBe complex ID: PDB-CPX-273130 (Preferred)   search this ID
PDBe-KB: P25024    P62873    P63096    P59768    P10145   
Electron Microscopy
3.41Å resolution
Released: 19 Jul 2023
Model geometry
Fit model/data
Data not analysed
8ic0
8ic0
8ic0
Solution NMR CXCL8-CXCR1 N-domain complex structure
Sepuru KM, Rajarathnam K
To be published
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: C-X-C chemokine receptor type 1 and Interleukin-8 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145179 (Preferred)   search this ID
PDBe-KB: P25024    P10145   
Solution NMR
Released: 7 Jul 2021
Model geometry
Fit model/data
Data not analysed
6xmn
6xmn
6xmn
CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8
Skelton NJ, Quan C, Lowman H
Structure (1999) [PMID: 10368283  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: ACA    ACE    ACE    NH2    NH2   
Assembly name: CXCL8-CXCR1 receptor-ligand complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145182 (Preferred)   search this ID
PDBe-KB: P25024    P10145   
Solution NMR
Released: 23 Dec 1998
Model geometry
Fit model/data
Data not analysed
1ilp
1ilp
1ilp
Structure of human CXCR1 in phospholipid bilayers
Park S, Das BB, Casagrande F, Nothnagel H, Chu M, Kiefer H, Maier K, De Angelis A, Marassi FM, Opella SJ
Nature (2012) [PMID: 23086146  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: C-X-C chemokine receptor type 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-150329 (Preferred)   search this ID
PDBe-KB: P25024   
Solid-state NMR
Released: 17 Oct 2012
Model geometry
Fit model/data
Data not analysed
2lnl
2lnl
2lnl
CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8 (MINIMIZED MEAN)
Skelton NJ, Quan C, Lowman H
Structure (1999) [PMID: 10368283  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: ACA    ACE    ACE    NH2    NH2   
Assembly name: CXCL8-CXCR1 receptor-ligand complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145182 (Preferred)   search this ID
PDBe-KB: P25024    P10145   
Solution NMR
Released: 23 Dec 1998
Model geometry
Fit model/data
Data not deposited
1ilq
1ilq
1ilq
Entries 1 to 5 of 5
Entries 1 to 5 of 5