Entry status  (1)

REL

(64)

Experimental methods  (2)

X-ray diffraction

(62)

Solution NMR

(2)

Authors  (207)

Stuehr DJ

(35)

Getzoff ED

(34)

Tainer JA

(34)

Arvai AS

(29)

Crane BR

(26)

Rosenfeld RJ

(23)

Wallace AV

(22)

Aberg A

(21)

Andersson G

(20)

Garcin ED

(20)

Andrews G

(17)

Cheshire DR

(17)

Connolly S

(17)

Hamley PJ

(17)

Mete A

(17)

Nicholls DJ

(17)

St-Gallay SA

(17)

Gensmantel NP

(15)

Kroeger MD

(15)

Mallinder PR

(15)

Tinker AC

(15)

Ghosh DK

(12)

Whitlow M

(9)

Adler M

(7)

Devlin JJ

(7)

Erickson S

(7)

Ghosh S

(7)

Morrissey MM

(7)

Pan G

(7)

Stueh DJ

(7)

Vergona R

(7)

Arnaiz D

(6)

Davey DD

(6)

Eagen K

(6)

Guilford W

(6)

Kenrick M

(6)

Ohlmeyer M

(6)

Paradkar VM

(6)

Parkinson J

(6)

Phillips G

(6)

Polokoff M

(6)

Saionz K

(6)

Santos C

(6)

Subramanyam B

(6)

Wei RG

(6)

Wu C

(6)

Ye B

(6)

Zhao ZS

(6)

Morris GM

(5)

Olson AJ

(5)

Panda K

(5)

Arnaia D

(4)

Fedorov R

(4)

Kuang Z

(4)

Li H

(4)

Li K

(4)

Ohimeyer M

(4)

Salonz K

(4)

Schlichting I

(4)

Blasko E

(3)

Gachhui R

(3)

Glaser CB

(3)

Luo Y

(3)

Parkinson JF

(3)

Poulos TL

(3)

Young TA

(3)

Andersson GM

(2)

Aoyagi M

(2)

Beaton HG

(2)

Birkinshaw TN

(2)

Boughton-Smith N

(2)

Cook TR

(2)

Cooper A

(2)

Cooper SL

(2)

Cox D

(2)

Dieckmann T

(2)

Dixon J

(2)

Gensmantel N

(2)

Guillemette JG

(2)

Harrison R

(2)

Hartmann E

(2)

Hartopp P

(2)

Kack H

(2)

Käck H

(2)

Leeson PD

(2)

Luker T

(2)

Millichip I

(2)

Misra S

(2)

Page RC

(2)

Piazza M

(2)

Pimm AD

(2)

Raman CS

(2)

Wang Y

(2)

Wei H

(2)

You T

(2)

Zhang D

(2)

Åberg A

(2)

Alber T

(1)

Andersson GMK

(1)

Anezo C

(1)

 

More...

Homo / hetero assembly  (2)

homo

(55)

hetero

(9)

Assembly composition  (2)

protein structure

(55)

protein/protein complex

(9)

Assembly polymer count  (4)

dimer

(57)

monomer

(4)

tetramer

(2)

trimer

(1)

Resolution distribution

1.0 - 1.5

(4)

1.5 - 2

(7)

2.0 - 2.5

(25)

2.5 - 3

(24)

3.0 - 3.5

(2)

Release year distribution

1995 - 2000

(15)

2000 - 2005

(20)

2005 - 2010

(26)

2010 - 2015

(8)

2015 - 2020

(5)

2020 - 2025

(3)

Journal  (16)

Nat Chem Biol

(15)

Biochemistry

(13)

J Biol Chem

(6)

J Med Chem

(6)

Science

(6)

To be published

(4)

Bioorg Med Chem Lett

(3)

EMBO J

(2)

Proc Natl Acad Sci U S A

(2)

Arch Biochem Biophys

(1)

Biochem Biophys Res Commun

(1)

Bioorg Med Chem

(1)

J. Biol. Chem.

(1)

Nat Struct Biol

(1)

Nitric Oxide

(1)

Org Biomol Chem

(1)

Organism superkingdom  (1)

Eukaryota

(64)

Organism name  (2)

Mus musculus

(51)

Homo sapiens

(13)

Molecule name  (10)

Inducible NO synthase

(64)

Inducible NOS

(64)

NOS type II

(64)

Nitric oxide synthase, inducible

(64)

Peptidyl-cysteine S-nitrosylase NOS2

(64)

iNOS

(64)

MAC-NOS

(51)

Macrophage NOS

(51)

HEP-NOS

(13)

Hepatocyte NOS

(13)

Molecule type  (1)

Protein

(64)

Gene names  (4)

Inosl

(51)

Nos2

(51)

NOS2

(13)

NOS2A

(13)

Interacting Molecules  (4)

SPRY domain-containing SOCS box protein 2

(4)

Calmodulin-1

(3)

Calmodulin

(1)

Nitric oxide synthase, inducible

(1)

Interacting ligands  (56)

HEM : PROTOPORPHYRIN IX CONTAINING FE

(54)

H4B : 5,6,7,8-TETRAHYDROBIOPTERIN

(41)

SO4 : SULFATE ION

(24)

ZN : ZINC ION

(12)

EDO : 1,2-ETHANEDIOL

(9)

BOG : octyl beta-D-glucopyranoside

(7)

GOL : GLYCEROL

(6)

IMD : IMIDAZOLE

(4)

ARG : ARGININE

(3)

AT2 : ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE

(3)

HAR : N-OMEGA-HYDROXY-L-ARGININE

(3)

HBI : 7,8-DIHYDROBIOPTERIN

(3)

ITU : ETHYLISOTHIOUREA

(3)

H2B : 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE

(2)

SO3 : SULFITE ION

(2)

14W : N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE

(1)

1A2 : 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE

(1)

1PM : methyl (3S)-3-{2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethyl}-4-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]piperazine-1-carboxylate

(1)

228 : N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE

(1)

328 : 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile

(1)

329 : (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine

(1)

332 : (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine

(1)

333 : 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE

(1)

342 : (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE

(1)

391 : 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE

(1)

3AR : N-OMEGA-PROPYL-L-ARGININE

(1)

4AB : 2,4-DIAMINO-6-[2,3-DIHYDROXY-PROP-3-YL]-5,6,7,8-TETRAHYDROPTERIDINE

(1)

5NI : 5-NITROINDAZOLE

(1)

6NI : 6-NITROINDAZOLE

(1)

7NI : 7-NITROINDAZOLE

(1)

A11 : ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE

(1)

A54 : 2-[(1R)-3-amino-1-phenyl-propoxy]-4-chloro-benzonitrile

(1)

A55 : N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE

(1)

AGU : AMINOGUANIDINE

(1)

ARR : N-(4-{2-[(3-CHLOROBENZYL)AMINO]ETHYL}PHENYL)THIOPHENE-2-CARBOXIMIDAMIDE

(1)

AS3 : 4-METHYL-6-PROPYLPYRIDIN-2-AMINE

(1)

AT6 : N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE

(1)

B14 : 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE

(1)

B2 : (2R)-5-FLUORO-2-(2-THIENYL)-1,2-DIHYDROQUINAZOLIN-4-AMINE

(1)

BVF : 4-METHYLPYRIDIN-2-AMINE

(1)

CLW : CHLORZOXAZONE

(1)

FC1 : THIOCOUMARIN

(1)

FMN : FLAVIN MONONUCLEOTIDE

(1)

HEC : HEME C

(1)

I58 : 4R-FLUORO-N6-ETHANIMIDOYL-L-LYSINE

(1)

INE : 3-BROMO-7-NITROINDAZOLE

(1)

MH0 : Mesoheme

(1)

MPW : 2-[2-(4-methoxypyridin-2-yl)ethyl]-3H-imidazo[4,5-b]pyridine

(1)

MR1 : 1-(1,3-BENZODIOXOL-5-YL)METHANAMINE

(1)

MSR : 4-(1H-IMIDAZOL-1-YL)PHENOL

(1)

NO : NITRIC OXIDE

(1)

R86 : 2-{(2R)-4-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-1-ISOBUTYRYLPIPERAZIN-2-YL}-N-[2-(4-METHOXYPHENYL)ETHYL]ACETAMIDE

(1)

S71 : (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine

(1)

SCI : L-THIOCITRULLINE

(1)

XXZ : 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE

(1)

YWO : O-(5-methyl-2-nitrophenyl)-D-tyrosinamide

(1)

EC number / name  (1)

1.14.13.39 : Nitric-oxide synthase (NADPH)

(64)

Biological function  (3)

nitric-oxide synthase activity

(56)

heme binding

(18)

FMN binding

(1)

Biological process  (1)

nitric oxide biosynthetic process

(56)

Compound cofactor class  (2)

Heme

(56)

Flavin Mononucleotide

(1)

SCOP fold  (1)

Nitric oxide (NO) synthase oxygenase domain

(42)

SCOP family  (1)

Nitric oxide (NO) synthase oxygenase domain

(42)

CATH class  (2)

Alpha Beta

(56)

Special

(1)

CATH topology  (5)

Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3

(55)

Nitric Oxide Synthase; Chain A, domain 1

(55)

Nitric Oxide Synthase;Heme Domain; Chain A, domain 2

(55)

Rossmann fold

(1)

Single alpha-helices involved in coiled-coils or other helix-helix interfaces

(1)

Pfam accession / name  (2)

PF02898 : NO_synthase

(56)

PF00258 : Flavodoxin_1

(1)

Diffraction protocol  (1)

Single wavelength

(56)

Diffraction radiation source type  (2)

Synchrotron

(60)

Rotating anode

(2)

Diffraction source  (22)

SSRL BEAMLINE BL9-1

(17)

SSRL BEAMLINE BL7-1

(15)

ALS BEAMLINE 5.0.2

(6)

APS BEAMLINE 14-BM-C

(2)

ESRF BEAMLINE ID14-1

(2)

MAX II BEAMLINE I711

(2)

NFPSS BEAMLINE BL19U1

(2)

SSRF BEAMLINE BL19U1

(2)

ALS BEAMLINE 4.2.2

(1)

ALS BEAMLINE 8.3.1

(1)

APS BEAMLINE 17-BM

(1)

APS BEAMLINE 17-ID

(1)

CHESS BEAMLINE F1

(1)

EMBL/DESY, HAMBURG BEAMLINE X13

(1)

EMBL/DESY, HAMBURG BEAMLINE X31

(1)

ESRF BEAMLINE ID14-3

(1)

ESRF BEAMLINE ID14-4

(1)

NSLS BEAMLINE X12C

(1)

RIGAKU MICROMAX-007

(1)

RIGAKU MICROMAX-007 HF

(1)

SSRL BEAMLINE BL11-1

(1)

SSRL BEAMLINE BL9-2

(1)

Synchrotron site  (10)

SSRL

(34)

ALS

(8)

APS

(4)

ESRF

(4)

EMBL/DESY, Hamburg

(2)

MAX II

(2)

NFPSS

(2)

SSRF

(2)

CHESS

(1)

NSLS

(1)

Diffraction detector type  (3)

CCD

(28)

Image plate

(28)

Pixel

(5)

Refinement software  (6)

CNS

(36)

X-PLOR

(17)

REFMAC

(6)

CNX

(4)

PHENIX

(2)

BUSTER

(1)

NMR software packages  (2)

CNS

(2)

CARA

(1)

NMR Field Strength

500.0 - 600

(2)

600.0 - 700

(2)

700.0 - 800

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%