Uniprot accession / id : P35270  OR   Uniprot accession / id : Q17QK8  OR   Uniprot accession / id : E1C4L3  OR   Uniprot accession / id : B3DJY2  OR   Uniprot accession / id : O76752  OR   Uniprot accession / id : Q7PJ32
 
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Entry Information
Entry status  (1)
REL
(14)
 
Experimental methods  (1)
X-ray diffraction
(14)
 
Authors  (65)
Alen J
(6)
Bahrenberg G
(6)
Blaesse M
(6)
Christian F
(6)
Dunkern TR
(6)
Merla B
(6)
Nordhoff S
(6)
Ratcliffe P
(6)
Schade M
(6)
Wagener M
(6)
Johnsson K
(5)
Pojer F
(4)
Groenlund Pedersen M
(3)
Haruki H
(3)
Pedersen MG
(3)
Gorska KI
(2)
Hovius R
(2)
Andrews N
(1)
Andrews P
(1)
Arrowsmith C
(1)
Babaniyi O
(1)
Barrett LB
(1)
Blagg J
(1)
Channon KM
(1)
Cheng W
(1)
Chuaiphichai S
(1)
Costigan M
(1)
Cronin SJ
(1)
Duong K
(1)
Edwards A
(1)
Ferreiros N
(1)
Ferreirós N
(1)
Fujita M
(1)
Gao H
(1)
Gorska K
(1)
Gorszka KI
(1)
Huang X
(1)
Huang Y
(1)
Kavanagh K
(1)
Latini A
(1)
Latremoliere A
(1)
Lin D
(1)
Lv Z
(1)
Meng Q
(1)
Miracca G
(1)
Naylor A
(1)
Ng S
(1)
Oppermann U
(1)
Painter M
(1)
Penninger JM
(1)
Remor AP
(1)
Riva P
(1)
Romero C
(1)
Schneider S
(1)
Sparling BA
(1)
Structural Genomics Consortium (SGC)
(1)
Sundstrom M
(1)
Tegeder I
(1)
Ugochukwu E
(1)
Wang F
(1)
Wang K
(1)
Woolf CJ
(1)
Zhang B
(1)
Zhong J
(1)
von Delft F
(1)
 
Homo / hetero assembly  (1)
homo
(14)
 
Assembly composition  (1)
protein structure
(14)
 
Assembly polymer count  (2)
dimer
(13)
monomer
(1)
 
Resolution distribution
1.0 - 1.5
(1)
1.5 - 2
(6)
2.0 - 2.5
(5)
2.5 - 3
(2)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(5)
2015 - 2020
(9)
2020 - 2025
(1)
 
Journal  (6)
J Med Chem
(6)
To be published
(3)
Science
(2)
Bioorg Med Chem Lett
(1)
J Biol Chem
(1)
Neuron
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(14)
 
Organism name  (1)
Homo sapiens
(14)
 
Molecule type  (1)
Protein
(14)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 14
Entries 1 to 10 of 14
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The Crystal Structure of human SPR from Biortus.
Wang F, Lv Z, Cheng W, Lin D, Meng Q, Zhang B, Huang Y
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ACT    ZN    NAP    ZN    ACT   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.8Å resolution
Released: 13 Jan 2021
Model geometry
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7dsf
7dsf
7dsf
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: H4H    NAP    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.72Å resolution
Released: 10 Jul 2019
Model geometry
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6i6c
6i6c
6i6c
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 3
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: H4T    NAP    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.62Å resolution
Released: 10 Jul 2019
Model geometry
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6i6p
6i6p
6i6p
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 1
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: H4E    NAP    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.94Å resolution
Released: 10 Jul 2019
Model geometry
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6i6f
6i6f
6i6f
Co-crystal structure of SPR with compound 5
Huang X, Wang K
Bioorg Med Chem Lett (2020) [PMID: 31740247  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PEG    QGV    GOL    PEG    QGV    NAP    SO4   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152879 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
2.773Å resolution
Released: 11 Dec 2019
Model geometry
Data not analysed
Fit model/data
Data not analysed
6usn
6usn
6usn
Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid
Johnsson K
J Biol Chem (2016) [PMID: 26565027  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: 4KL    NAP    SO4    4KL    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
2.35Å resolution
Released: 18 Nov 2015
Model geometry
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Data not analysed
4z3k
4z3k
4z3k
Crystal structure of human sepiapterin reductase in complex with sulfapyridine
Groenlund Pedersen M, Pojer F, Johnsson K
Science (2013) [PMID: 23704574  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: SFY    PEG    SFY    GOL    PEG    NAP    SO4   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
2.4Å resolution
Released: 5 Jun 2013
Model geometry
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4hwk
4hwk
4hwk
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 6
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: H6E    NAP    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.43Å resolution
Released: 10 Jul 2019
Model geometry
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6i6v
6i6v
6i6v
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 5
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAP    H5B    EDO   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.79Å resolution
Released: 10 Jul 2019
Model geometry
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6i6t
6i6t
6i6t
SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 4
Alen J, Schade M, Wagener M, Blaesse M
J Med Chem (2019) [PMID: 31244106  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: NAP    H5E   
Assembly name: Sepiapterin reductase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152880 (Preferred)   search this ID
PDBe-KB: P35270   
X-ray diffraction
1.63Å resolution
Released: 10 Jul 2019
Model geometry
Fit model/data
6i79
6i79
6i79
Entries 1 to 10 of 14
Entries 1 to 10 of 14