Entry status  (1)

REL

(8)

Experimental methods  (3)

Electron Microscopy

(3)

X-ray diffraction

(3)

Solution NMR

(2)

Authors  (68)

Hay DL

(4)

Booe JM

(3)

Pioszak AA

(3)

Warner ML

(3)

Belousoff MJ

(2)

Booe J

(2)

Christopoulos A

(2)

Danev R

(2)

Deganutti G

(2)

Fletcher MM

(2)

Furness SGB

(2)

Khoshouei M

(2)

Koole C

(2)

Liang YL

(2)

Miller LJ

(2)

Pioszak A

(2)

Reynolds CA

(2)

Sexton P

(2)

Sexton PM

(2)

Wootten D

(2)

Zhang X

(2)

Barwell J

(1)

Bill RM

(1)

Brimble MA

(1)

Chen X

(1)

Fang GX

(1)

Gao N

(1)

Guo L

(1)

Harris PW

(1)

Jamaluddin MA

(1)

Jimenez-Barbero J

(1)

Jiménez-Barbero J

(1)

Kotovych G

(1)

Kuteyi G

(1)

Li Y

(1)

Li Z

(1)

Liu L

(1)

Liu Q

(1)

Lucyk S

(1)

Martin-Santamaria S

(1)

Martinez A

(1)

Martín-Santamaría S

(1)

Martínez A

(1)

Miskolzie M

(1)

Nieto L

(1)

Pascual-Teresa B

(1)

Pascual-Teresa Bd

(1)

Perez-Castells J

(1)

Poyner DR

(1)

Pérez-Castells J

(1)

Qu C

(1)

Ramos A

(1)

Roehrkasse AM

(1)

Simms J

(1)

Sun JP

(1)

Taha H

(1)

Walker CS

(1)

Wang G

(1)

Wang J

(1)

Xiao P

(1)

Xu Y

(1)

Yamamoto H

(1)

Yan X

(1)

Yang F

(1)

Yu X

(1)

Zhang C

(1)

Zhou J

(1)

Zhu Z

(1)

Homo / hetero assembly  (2)

hetero

(6)

homo

(2)

Assembly composition  (2)

protein/protein complex

(6)

protein structure

(2)

Assembly polymer count  (3)

dimer

(4)

heptamer

(2)

monomer

(2)

Resolution distribution

1.5 - 2

(2)

2.0 - 2.5

(1)

2.5 - 3

(2)

3.0 - 3.5

(1)

Release year distribution

2005 - 2010

(1)

2010 - 2015

(2)

2015 - 2020

(5)

2020 - 2025

(4)

Journal  (5)

ACS Pharmacol Transl Sci

(3)

Biopolymers

(2)

Mol Cell

(1)

Mol Pharmacol

(1)

Nature

(1)

Organism superkingdom  (2)

Eukaryota

(8)

Bacteria

(3)

Organism name  (3)

Homo sapiens

(8)

Escherichia coli K-12

(2)

Escherichia coli O157:H7

(1)

Molecule name  (32)

AM

(8)

Adrenomedullin

(8)

PAMP

(8)

Pro-adrenomedullin

(8)

ProAM N-terminal 20 peptide

(8)

ProAM-N20

(8)

Proadrenomedullin N-20 terminal peptide

(8)

CGRP type 1 receptor

(5)

CRLR

(5)

Calcitonin gene-related peptide type 1 receptor

(5)

Calcitonin receptor-like receptor

(5)

CRLR activity-modifying protein 2

(3)

Calcitonin-receptor-like receptor activity-modifying protein 2

(3)

MBP

(3)

MMBP

(3)

Maltodextrin-binding protein

(3)

Maltose-binding protein

(3)

Maltose/maltodextrin-binding periplasmic protein

(3)

Receptor activity-modifying protein 2

(3)

Adenylate cyclase-stimulating G alpha protein

(2)

G gamma-I

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(2)

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

(2)

Transducin beta chain 1

(2)

CRLR activity-modifying protein 1

(1)

CRLR activity-modifying protein 3

(1)

Calcitonin-receptor-like receptor activity-modifying protein 1

(1)

Calcitonin-receptor-like receptor activity-modifying protein 3

(1)

Mas-related G-protein coupled receptor member X2

(1)

Receptor activity-modifying protein 1

(1)

Receptor activity-modifying protein 3

(1)

Molecule type  (1)

Protein

(8)

Gene names  (17)

ADM

(8)

AM

(8)

CALCRL

(5)

CGRPR

(5)

JW3994

(3)

RAMP2

(3)

b4034

(3)

malE

(3)

GNAS

(2)

GNAS1

(2)

GNB1

(2)

GNG2

(2)

GSP

(2)

MRGPRX2

(1)

MRGX2

(1)

RAMP1

(1)

RAMP3

(1)

Interacting Molecules  (12)

Adrenomedullin

(5)

Calcitonin gene-related peptide type 1 receptor

(5)

Maltose/maltodextrin-binding periplasmic protein

(3)

Receptor activity-modifying protein 2

(3)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

(2)

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(2)

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

(2)

Nanobody 35

(2)

Mas-related G-protein coupled receptor member X2

(1)

Proadrenomedullin N-20 terminal peptide

(1)

Receptor activity-modifying protein 1

(1)

Receptor activity-modifying protein 3

(1)

Interacting ligands  (6)

GLC : alpha-D-glucopyranose

(3)

PRD_900001 : alpha-maltose

(3)

CLR : CHOLESTEROL

(1)

EDO : 1,2-ETHANEDIOL

(1)

FMT : FORMIC ACID

(1)

NH2 : AMINO GROUP

(1)

Biological function  (27)

G protein-coupled receptor activity

(6)

coreceptor activity

(5)

hormone activity

(4)

carbohydrate transmembrane transporter activity

(3)

D1 dopamine receptor binding

(2)

G protein activity

(2)

G-protein beta-subunit binding

(2)

G-protein beta/gamma-subunit complex binding

(2)

GTP binding

(2)

GTPase activity

(2)

GTPase binding

(2)

adenylate cyclase activator activity

(2)

adrenomedullin receptor activity

(2)

calcitonin receptor activity

(2)

guanyl nucleotide binding

(2)

hydrolase activity

(2)

metal ion binding

(2)

nucleotide binding

(2)

protein binding

(2)

protein-containing complex binding

(2)

signaling receptor complex adaptor activity

(2)

transmembrane signaling receptor activity

(2)

adrenomedullin binding

(1)

amylin receptor activity

(1)

amyloid-beta binding

(1)

mast cell secretagogue receptor activity

(1)

neuropeptide binding

(1)

Biological process  (72)

G protein-coupled receptor signaling pathway

(6)

intracellular protein transport

(5)

regulation of G protein-coupled receptor signaling pathway

(5)

carbohydrate transport

(3)

signal transduction

(3)

transmembrane transport

(3)

G protein-coupled acetylcholine receptor signaling pathway

(2)

Ras protein signal transduction

(2)

activation of adenylate cyclase activity

(2)

adenylate cyclase-activating G protein-coupled receptor signaling pathway

(2)

adenylate cyclase-activating adrenergic receptor signaling pathway

(2)

adenylate cyclase-activating dopamine receptor signaling pathway

(2)

adrenomedullin receptor signaling pathway

(2)

bone development

(2)

calcium ion transport

(2)

cell population proliferation

(2)

cell surface receptor signaling pathway

(2)

cellular response to catecholamine stimulus

(2)

cellular response to glucagon stimulus

(2)

cellular response to hormone stimulus

(2)

cellular response to prostaglandin E stimulus

(2)

cognition

(2)

developmental growth

(2)

fibroblast proliferation

(2)

hair follicle placode formation

(2)

intracellular transport

(2)

negative regulation of inflammatory response to antigenic stimulus

(2)

phospholipase C-activating G protein-coupled receptor signaling pathway

(2)

platelet aggregation

(2)

positive regulation of cold-induced thermogenesis

(2)

positive regulation of gene expression

(2)

protein localization to plasma membrane

(2)

protein transport

(2)

receptor internalization

(2)

regulation of insulin secretion

(2)

renal water homeostasis

(2)

retina development in camera-type eye

(2)

sensory perception of smell

(2)

sensory perception of taste

(2)

vascular endothelial cell response to laminar fluid shear stress

(2)

G protein-coupled receptor signaling pathway involved in heart process

(1)

adherens junction assembly

(1)

amylin receptor 2 signaling pathway

(1)

amylin receptor 3 signaling pathway

(1)

amylin receptor signaling pathway

(1)

angiogenesis

(1)

basement membrane assembly

(1)

bicellular tight junction assembly

(1)

cellular response to estradiol stimulus

(1)

cellular response to vascular endothelial growth factor stimulus

(1)

cross-receptor inhibition within G protein-coupled receptor heterodimer

(1)

heart development

(1)

mast cell activation

(1)

mast cell degranulation

(1)

negative regulation of endothelial cell apoptotic process

(1)

negative regulation of vascular permeability

(1)

positive regulation of ERK1 and ERK2 cascade

(1)

positive regulation of angiogenesis

(1)

positive regulation of cAMP/PKA signal transduction

(1)

positive regulation of calcium-mediated signaling

(1)

positive regulation of cytokinesis

(1)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

(1)

positive regulation of protein localization to plasma membrane

(1)

positive regulation of receptor recycling

(1)

positive regulation of vasculogenesis

(1)

regulation of blood pressure

(1)

response to amyloid-beta

(1)

sensory perception of pain

(1)

sleep

(1)

sprouting angiogenesis

(1)

vascular associated smooth muscle cell development

(1)

vasculogenesis

(1)

Biological cell component  (19)

membrane

(6)

extracellular region

(4)

plasma membrane

(3)

adrenomedullin receptor complex

(2)

cell surface

(2)

cytoplasm

(2)

cytosol

(2)

extracellular exosome

(2)

extracellular vesicle

(2)

heterotrimeric G-protein complex

(2)

lysosomal membrane

(2)

lysosome

(2)

photoreceptor disc membrane

(2)

photoreceptor outer segment

(2)

receptor complex

(2)

synapse

(2)

trans-Golgi network membrane

(2)

amylin receptor complex 3

(1)

clathrin-coated pit

(1)

Pfam accession / name  (9)

PF02793 : HRM

(5)

PF04901 : RAMP

(5)

PF00214 : Calc_CGRP_IAPP

(3)

PF01547 : SBP_bac_1

(3)

PF00002 : 7tm_2

(2)

PF00400 : WD40

(2)

PF00503 : G-alpha

(2)

PF00631 : G-gamma

(2)

PF00001 : 7tm_1

(1)

Diffraction protocol  (1)

Single wavelength

(4)

Diffraction radiation source type  (1)

Synchrotron

(3)

Diffraction source  (1)

APS BEAMLINE 21-ID-G

(3)

Synchrotron site  (1)

APS

(3)

Diffraction detector type  (1)

CCD

(3)

Refinement software  (2)

PHENIX

(3)

REFMAC

(2)

EM microscope model  (1)

FEI TITAN KRIOS

(3)

EM detector name  (2)

GATAN K3 (6k x 4k)

(2)

GATAN K2 SUMMIT (4k x 4k)

(1)

NMR software packages  (5)

Amber

(1)

CNS

(1)

CYANA

(1)

NMRView

(1)

VNMR

(1)

NMR Field Strength

500.0 - 600

(1)

600.0 - 700

(1)

700.0 - 800

(2)

800.0 - 900

(2)

Representative Structures

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95%

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